关键信息
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基因名
CXCR3
- 应用
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别名
CD183; CKR-L2; CMKAR3; GPR9; IP10r; IP10-R; Mig-R; MigR; G Protein-Coupled Receptor 9; Interferon-inducible protein 10 receptor; IP-10 receptor
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P49682
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表达区间
Met1~Arg53+Val111~Lys125+Leu190~Arg212+Asp278~Val298
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分子量
16kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
CXCR3 is a chemokine receptor that plays a critical role in the immune response by regulating the migration and activation of various immune cells, particularly T cells. It is involved in the inflammatory processes associated with chronic diseases such as cancer, autoimmune disorders, and viral infections. Extensive research has shown that CXCR3 is activated by specific chemokines, leading to cellular signaling pathways that influence cell survival, proliferation, and function. The recombinant expression of CXCR3 protein has become a vital tool in understanding its biological functions and therapeutic potential. By producing CXCR3 in a laboratory setting, researchers can study its interactions with ligands and other cellular components, elucidate the receptor's role in disease mechanisms, and explore strategies for modulating its activity for therapeutic use. This research has implications for developing targeted therapies that can enhance or inhibit CXCR3 signaling, paving the way for innovative treatment approaches in immune-mediated diseases. Overall, the study of CXCR3 recombinant protein not only contributes to the fundamental knowledge of immune regulation but also holds promise for advancing clinical applications in immunotherapy and personalized medicine.
