关键信息
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基因名
LAMTOR3
- 应用
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别名
Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3
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种属
Human
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表达系统
E. coli
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标签
N- GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UHA4
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表达区间
1-124aa
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分子量
40.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
LAMTOR3, part of the late endosomal/lysosomal adaptor and MAPK signaling regulator (LAMTOR) complex, plays a crucial role in the regulation of various cellular processes, particularly in lysosomal function and the mTOR (mechanistic target of rapamycin) signaling pathway. Research into LAMTOR3 has gained prominence due to its involvement in cellular growth, proliferation, and metabolism—key processes linked to cancer and metabolic disorders. Abnormalities in LAMTOR3 expression or function can lead to dysregulation of mTOR signaling, which is critically associated with tumorigenesis and other diseases. Moreover, LAMTOR3 is implicated in the regulation of autophagy, a vital process for cellular homeostasis. As such, studying the recombinant protein of LAMTOR3 is essential for understanding its functional mechanisms and interactions within the LAMTOR complex. This research not only sheds light on fundamental cellular biology but also holds potential therapeutic implications for targeting mTOR-related pathways in various diseases, including cancer and neurodegenerative disorders. The engineering and characterization of recombinant LAMTOR3 could provide valuable insights into its structural properties and assist in the identification of novel therapeutic targets, thereby contributing to the development of innovative treatments.
