关键信息
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基因名
MLF1
- 应用
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别名
Myelodysplasia-myeloid leukemia factor 1
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种属
Human
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表达系统
E. coli
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标签
N- GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P58340
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表达区间
1-268aa
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分子量
57.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
MLF1 (myeloid leukemia factor 1) is a protein that has garnered significant attention in the field of cancer research, particularly due to its role in hematopoietic malignancies. Initially identified as a gene associated with myeloid leukemia, MLF1 is implicated in the regulation of cell growth and differentiation, making it a critical factor in understanding leukemogenesis. Studies have shown that MLF1 can influence various cellular pathways, including those related to cell cycle regulation and apoptosis. Moreover, it has been found to interact with other proteins involved in transcriptional regulation, suggesting its role in modulating gene expression in hematopoietic cells. The presence of MLF1 in leukemic blasts further emphasizes its potential as a biomarker for disease progression and prognosis in acute myeloid leukemia (AML). Researchers are investigating MLF1 as a therapeutic target, aiming to devise strategies that inhibit its oncogenic functions or restore normal cellular processes. Additionally, the recombinant production of MLF1 protein is essential for in-depth studies of its structure-function relationships, as well as its role in cellular signaling pathways. Understanding MLF1’s mechanism of action could provide insights into novel therapeutic approaches for leukemia and potentially other cancers, highlighting its importance in both basic and translational research efforts. Overall, the study of MLF1 and its implications in tumor biology represents a promising frontier in the quest for targeted cancer therapies.
