关键信息
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基因名
NANOS2
- 应用
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别名
NANO2_HUMAN; Nanos homolog 2; Nanos homolog 2 Drosophila; NANOS2; NOS-2; NOS2
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P60321
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表达区间
1-138aa
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分子量
31.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
NANOS2 is a member of the NANOS family of RNA-binding proteins, which play crucial roles in germ cell development and the maintenance of pluripotency in embryonic stem cells. Research into NANOS2 has gained significance due to its pivotal role in the regulation of germline-specific gene expression and its involvement in the suppression of transcription during early embryonic development. In many organisms, including mice and humans, NANOS2 is essential for the proper formation and differentiation of primordial germ cells. The protein functions by binding to specific mRNAs, facilitating their stability or degradation, and thus influencing the fate of germ cells. Recent studies have shown that perturbations in NANOS2 function can lead to reproductive issues and link it to various developmental disorders. Given its important biological functions, understanding the mechanisms of NANOS2 has implications for reproductive biology, developmental biology, and potential therapeutic applications in regenerative medicine and infertility treatment. Consequently, the characterization of NANOS2 recombinant protein has become a crucial focus for researchers aiming to elucidate its biochemical properties, interaction partners, and functional pathways within the cell. Overall, NANOS2 serves as a vital component in the regulation of germline development, and ongoing investigations into its properties will enhance our understanding of germ cell biology and inform potential clinical applications.
