关键信息
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基因名
PNMA1
- 应用
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别名
37KDA neuronal protein Neuron- and testis-specific protein 1
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种属
Human
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表达系统
E. coli
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标签
N- His-B2M-JD & C- Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8ND90
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表达区间
1-353aa
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分子量
46.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
PNMA1, or Parkinsonism-Associated Protein 1, has emerged as a critical target in neurobiological research due to its potential involvement in neurodegenerative diseases, including Parkinson's disease. Initial studies suggested that PNMA1 is expressed in neurons and may play a role in neuronal survival and differentiation. Its overexpression has been linked to cytotoxicity, while its downregulation appears to be associated with neurodegenerative processes. Research into the structural and functional properties of PNMA1, including its interactions with other cellular proteins and its role in cellular pathways, has gained momentum. Recombinant PNMA1 protein is increasingly being used in biochemical assays to elucidate its function and mechanism of action in neuronal cells. The production of this recombinant protein allows for the exploration of its aggregation properties, post-translational modifications, and potential as a biomarker for Parkinson's disease. Furthermore, studying PNMA1 through recombinant technology may pave the way for the development of therapeutic strategies aimed at modulating its activity, thereby contributing to a better understanding of the molecular underpinnings of neurodegeneration. These investigations are essential for determining the broader implications of PNMA1 in health and disease, ultimately enhancing our knowledge of neurobiology and advancing potential treatment avenues.
