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| 纯度 | >98%SDS-PAGE. |
| 种属 | mouse |
| 靶点 | CXCL16 |
| Uniprot No | Q8BSU2 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 27-114aa |
| 氨基酸序列 | NQGSVAGSCS CDRTISSGTQ IPQGTLDHIR KYLKAFHRCP FFIRFQLQSK SVCGGSQDQW VRELVDCFER KECGTGHGKS FHHQKHLP |
| 预测分子量 | 28 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于CXCL16重组蛋白的3篇参考文献的简要信息(注：文献为虚拟示例，实际引用需根据真实论文调整)：
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1. **文献名称**: *CXCL16/SR-PSOX mediates macrophage polarization and promotes atherosclerosis*
**作者**: Smith A, et al.
**摘要**: 研究揭示了重组CXCL16蛋白通过激活NF-κB信号通路，促进巨噬细胞向促炎表型极化，从而加剧动脉粥样硬化斑块形成。
2. **文献名称**: *Recombinant CXCL16 induces antitumor immunity by enhancing dendritic cell migration*
**作者**: Zhang L, et al.
**摘要**: 该文献报道CXCL16重组蛋白通过结合受体CXCR6.增强树突状细胞的迁移能力并激活T细胞抗肿瘤反应，为癌症免疫治疗提供新策略。
3. **文献名称**: *CXCL16 as a novel biomarker in liver fibrosis: Role of recombinant protein in stellate cell activation*
**作者**: Tanaka K, et al.
**摘要**: 实验证明CXCL16重组蛋白可激活肝星状细胞，促进胶原沉积，提示其作为肝纤维化潜在治疗靶点的价值。
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如需具体文献，建议通过PubMed或Web of Science检索关键词“CXCL16 recombinant protein”或结合研究领域(如炎症、肿瘤等)筛选近期论文。
CXCL16 is a unique member of the CXC chemokine family, functioning both as a chemotactic cytokine and a transmembrane scavenger receptor. It exists in two forms: a membrane-bound protein expressed on antigen-presenting cells (e.g., dendritic cells, macrophages) and epithelial cells, and a soluble form released through proteolytic cleavage. The membrane-bound CXCL16 mediates cell adhesion by interacting with its sole receptor, CXCR6. expressed on T cells, natural killer T (NKT) cells, and activated CD8+ T cells. The soluble form acts as a chemoattractant, directing the migration of CXCR6-expressing immune cells to inflammatory or tumor sites. Structurally, CXCL16 contains a chemokine domain, a mucin-like stalk, a transmembrane domain, and a cytoplasmic tail, distinguishing it from other chemokines.
Recombinant CXCL16 protein is produced using genetic engineering techniques, typically in mammalian expression systems to ensure proper post-translational modifications. This purified protein retains biological activity, enabling researchers to study CXCL16-CXCR6 signaling pathways, immune cell recruitment mechanisms, and its dual roles in inflammation and immune surveillance. Studies highlight its involvement in diseases such as atherosclerosis (via oxidized LDL uptake), cancer progression (modulating tumor microenvironment), and autoimmune disorders (e.g., rheumatoid arthritis). Recombinant CXCL16 is widely used in in vitro assays (e.g., cell migration, receptor binding) and animal models to explore therapeutic targeting. Its scavenger receptor function in pathogen clearance (e.g., bacteria, viruses) further underscores its immunological relevance. Research continues to unravel its context-dependent roles, balancing pro-inflammatory and homeostatic functions, making it a potential biomarker or therapeutic target in chronic diseases.
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