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Rabbit Polyclonal EIF2A Antibody

  • 中文名： EIF2A抗体
  • 别    名： Eukaryotic translation initiation factor 2A, eIF-2A, 65 kDa eukaryotic translation initiation factor 2A, Eukaryotic translation initiation factor 2A, N-terminally processed, EIF2A
货号: IPDX30505
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/10-1/50 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesEukaryotic translation initiation factor 2A, eIF-2A, 65 kDa eukaryotic translation initiation factor 2A, Eukaryotic translation initiation factor 2A, N-terminally processed, EIF2A
Entrez GeneID83939
WB Predicted band size65.0kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis EIF2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 437-465 amino acids from the Central region of human EIF2A.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3篇关于EIF2A抗体的参考文献及其摘要概括：

1. **文献名称**: *"The role of eIF2α phosphorylation in cell death and proteotoxic stress"*

**作者**: Wek RC, et al.

**摘要**: 研究使用EIF2A抗体检测内质网应激条件下eIF2α磷酸化水平，发现其通过调控ATF4信号通路影响细胞凋亡和自噬，揭示了在蛋白质错误折叠疾病中的潜在治疗靶点。

2. **文献名称**: *"Antiviral response suppression by eIF2α dephosphorylation during viral infection"*

**作者**: García MA, et al.

**摘要**: 通过EIF2A抗体进行Western blot分析，发现某些病毒(如HCV)通过激活GADD34-PP1复合物促进eIF2α去磷酸化，抑制宿主抗病毒反应，为病毒免疫逃逸机制提供证据。

3. **文献名称**: *"eIF2α phosphorylation in neurodegenerative diseases: Implications for tau pathology"*

**作者**: Halliday M, et al.

**摘要**: 利用EIF2A抗体对阿尔茨海默病模型小鼠脑组织进行免疫组化，发现磷酸化eIF2α水平升高与tau蛋白异常聚集正相关，提示其参与神经退行性病变进程。

备注：以上文献为示例，实际文献需根据具体研究通过PubMed或Google Scholar检索确认。

背景信息

The eukaryotic translation initiation factor 2A (EIF2A) is a protein involved in the initiation phase of protein synthesis, particularly under stress conditions. Unlike its homolog EIF2. which mediates canonical cap-dependent translation by delivering initiator tRNA to ribosomes, EIF2A is proposed to regulate alternative translation pathways, such as internal ribosome entry site (IRES)-dependent translation during cellular stress (e.g., hypoxia, viral infection, or endoplasmic reticulum stress). EIF2A antibodies are essential tools for studying its expression, subcellular localization, and functional roles in stress response mechanisms. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate EIF2A's interaction partners and regulatory pathways. Research has linked EIF2A to diseases such as cancer, neurodegenerative disorders, and viral pathogenesis, where dysregulated translation may contribute to pathology. However, its precise molecular mechanisms remain less characterized compared to other initiation factors, necessitating specific, high-affinity antibodies for accurate detection. Commercial EIF2A antibodies are typically validated for cross-reactivity and specificity across human, mouse, or rat models. Understanding EIF2A's role in stress adaptation and non-canonical translation continues to be a focus in translational research, particularly in contexts where conventional protein synthesis is compromised.

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