关键信息
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基因名
CDK5R1
- 应用
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别名
Cyclin-dependent kinase 5 activator 1(CDK5 activator 1)(Cyclin-dependent kinase 5 regulatory subunit 1)(TPKII regulatory subunit) [Cleaved into: Cyclin-dependent kinase 5 activator 1, p35(p35); Cyclin-dependent kinase 5 activator 1, p25(p25)(Tau protein kinase II 23 kDa subunit)(p23)]
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q15078
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表达区间
99-307aa
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分子量
27.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
CDK5R1, also known as cyclin-dependent kinase 5 regulatory subunit 1 or p35, is a pivotal protein that plays a critical role in the regulation of neuronal signaling and development. This protein acts as a regulatory subunit for CDK5, a kinase involved in various neuronal processes such as axon differentiation, synaptic plasticity, and cognitive functions. Dysregulation of CDK5 and its activators, including CDK5R1, has been implicated in a range of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. The study of CDK5R1 recombinant proteins is essential for understanding its structure and function, as well as its interactions with other molecular partners. Through recombinant protein techniques, researchers can produce CDK5R1 in a controlled environment, allowing for detailed biochemical and biophysical characterization. This research not only elucidates the role of CDK5R1 in normal neuronal physiology but also sheds light on its contribution to pathological processes. Understanding the functional implications of CDK5R1 and its regulatory mechanisms may open new avenues for therapeutic strategies aimed at treating neurodegenerative disorders. Hence, the investigation of CDK5R1 recombinant proteins represents a significant step toward unraveling the complexities of neuronal signaling pathways and their implications in health and disease.
