关键信息
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基因名
SOX1
- 应用
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别名
SOX1；Transcription factor SOX-1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O00570
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表达区间
1-391aa
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氨基酸序列
MYSMMMETDLHSPGGAQAPTNLSGPAGAGGGGGGGGGGGGGGGAKANQDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKVMSEAEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLLKKDKYSLAGGLLAAGAGGGGAAVAMGVGVGVGAAAVGQRLESPGGAAGGGYAHVNGWANGAYPGSVAAAAAAAAMMQEAQLAYGQHPGAGGAHPHAHPAHPHPHHPHAHPHNPQPMHRYDMGALQYSPISNSQGYMSASPSGYGGLPYGAAAAAAAAAGGAHQNSAVAAAAAAAAASSGALGALGSLVKSEPSGSPPAPAHSRAPCPGDLREMISMYLPAGEGGDPAAAAAAAAQSRLHSLPQHYQGAGAGVNGTVPLTHI
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分子量
46.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
SOX1, a member of the SRY-related HMG-box (SOX) transcription factor family, plays a critical role in early embryonic development and neural differentiation. Its involvement in the regulation of neural stem cell fate and maintenance has garnered significant interest, particularly in the context of neurodevelopmental disorders and cancers of the nervous system. Given SOX1's importance in these biological processes, the study of its recombinant protein provides valuable insights into its functional mechanisms. Researchers have been focusing on the structural and functional characterization of SOX1 recombinant proteins to elucidate their interactions with DNA and other protein partners in the regulatory networks controlling neural lineage specification. This research may reveal potential therapeutic targets for interventions in neural pathologies and enhance our understanding of the molecular underpinnings of neurogenesis. Additionally, the production and purification of SOX1 recombinant protein allow for biophysical analysis and the exploration of its role in the transcriptional regulation essential for cell fate determination. As a result, SOX1 represents a promising candidate for advanced studies aimed at harnessing its capabilities in regenerative medicine and stem cell therapy.
