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Rabbit Polyclonal HIST1H2BO/HIST1H2BH(N-term) Antibody

  • 中文名： HIST1H2BO/HIST1H2BH (N-term)抗体
  • 别    名： Histone H2B type 1-O, Histone H2B2, Histone H2Bn, H2B/n, HIST1H2BO, H2BFH, H2BFN
货号: IPDX31137
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesHistone H2B type 1-O, Histone H2B2, Histone H2Bn, H2B/n, HIST1H2BO, H2BFH, H2BFN
Entrez GeneID8348
WB Predicted band size13.9kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis HIST1H2BO/HIST1H2BH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human HIST1H2BO/HIST1H2BH.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

nan

背景信息

The HIST1H2BO and HIST1H2BH genes encode histone H2B family members, key components of nucleosomes that organize DNA into chromatin. These histones play critical roles in DNA packaging, gene regulation, and epigenetic inheritance. As part of the HIST1 cluster on chromosome 6p22.2. they belong to a multigene family with sequence variants that may fine-tune chromatin structure in a tissue- or context-specific manner. The N-terminal region of H2B histones is highly conserved and undergoes post-translational modifications (e.g., acetylation, ubiquitination) that influence chromatin dynamics. Antibodies targeting the N-terminus of HIST1H2BO/HIST1H2BH (often cross-reactive due to high sequence homology) are widely used to study nucleosome organization, DNA repair, and transcriptional regulation. They enable detection of H2B localization via techniques like ChIP-seq, immunofluorescence, or Western blot, and may also identify modification-specific epitopes when paired with enrichment methods. Such antibodies are valuable tools for investigating epigenetic mechanisms in development, cancer (where histone dysregulation is common), and other diseases linked to chromatin remodeling. Specificity validation via knockout controls is recommended due to potential cross-reactivity with other H2B variants.

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