关键信息
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基因名
NCOR2
- 应用
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别名
(N-CoR2)(CTG repeat protein 26)(SMAP270)(Silencing mediator of retinoic acid and thyroid hormone receptor)(SMRT)(T3 receptor-associating factor)(TRAC)(Thyroid-, retinoic-acid-receptor-associated corepressor)
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y618
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表达区间
1-312aa
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分子量
42.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
NCOR2, also known as Nuclear Receptor Corepressor 2, is a vital protein involved in the regulation of gene expression by repressing transcription mediated by nuclear hormone receptors. It plays a crucial role in diverse biological processes, including metabolism, cell differentiation, and circadian rhythm regulation. Research into NCOR2 has gained momentum due to its implications in various diseases, such as obesity, diabetes, and certain cancers, highlighting its potential as a therapeutic target. The reconstitution of NCOR2 as a recombinant protein allows for a detailed investigation into its structural and functional properties, facilitating the understanding of its interactions with other cellular components. Moreover, studying NCOR2 in vitro can help elucidate its role in transcriptional repression and its involvement in complex signaling pathways. Given the increasing awareness of NCOR2's impact on health and disease, characterizing its biochemical properties through recombinant expression is essential for developing novel pharmacological agents and therapeutic strategies aimed at modulating its function in disease contexts. Overall, the examination of NCOR2 as a recombinant protein offers promising avenues for research and may lead to significant advancements in the understanding and treatment of various metabolic and cancer-related disorders.
