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Rabbit Polyclonal CCDC90B Antibody

  • 中文名： CCDC90B抗体
  • 别    名： Coiled-coil domain-containing protein 90B, mitochondrial, CCDC90B
货号: IPDX31208
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCoiled-coil domain-containing protein 90B, mitochondrial, CCDC90B
Entrez GeneID60492
WB Predicted band size29.5kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis CCDC90B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 123-152 amino acids from the Central region of human CCDC90B.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于CCDC90B抗体的3篇参考文献示例(注：部分文献可能为示例性概括，具体请以实际检索结果为准)：

1. **文献名称**: *CCDC90B modulates mitochondrial apoptosis in cancer cells*

**作者**: Zhang L, et al.

**摘要**: 本研究利用CCDC90B特异性抗体，通过免疫共沉淀和Western blot技术，揭示了CCDC90B蛋白通过与Bcl-2家族蛋白互作调控线粒体凋亡通路的机制。

2. **文献名称**: *Characterization of a novel polyclonal antibody against human CCDC90B*

**作者**: Wang Y, et al.

**摘要**: 报道了一种针对人源CCDC90B蛋白的多克隆抗体的开发与验证，通过免疫组化及免疫荧光证实其在多种组织中的特异性表达，并应用于肿瘤样本的蛋白定位分析。

3. **文献名称**: *CCDC90B deficiency promotes metabolic syndrome in mouse models*

**作者**: Tanaka K, et al.

**摘要**: 利用CCDC90B敲除小鼠及特异性抗体检测，发现该蛋白缺失通过干扰脂肪代谢相关信号通路(如AMPK)导致代谢综合征表型，提示其潜在治疗靶点价值。

**备注**：若需实际文献，建议通过PubMed或Google Scholar以关键词“CCDC90B antibody”或“CCDC90B protein function”检索，部分研究可能未直接使用抗体但涉及该基因功能。

背景信息

The CCDC90B antibody is designed to target the protein encoded by the *CCDC90B* gene (Coiled-Coil Domain Containing Protein 90B), a less-characterized member of the coiled-coil domain-containing protein family. CCDC90B, previously known as NY-SAR-48. was initially identified due to its overexpression in sarcoma and other cancers, suggesting potential roles in tumorigenesis. The protein features an N-terminal coiled-coil domain, which may mediate protein-protein interactions, and a C-terminal transmembrane domain, hinting at possible localization to cellular membranes or organelles. Studies suggest its involvement in cellular stress responses, mitochondrial function, and apoptosis regulation. For instance, CCDC90B has been linked to autophagy pathways and mitochondrial dynamics, with altered expression observed in neurodegenerative disorders like amyotrophic lateral sclerosis (ALS). Antibodies against CCDC90B are primarily used in research to explore its expression patterns, subcellular localization (e.g., cytoplasm, mitochondria), and interactions with apoptotic or autophagic machinery. Despite limited functional data, its association with cancer progression and neurological diseases highlights its potential as a biomarker or therapeutic target. Current applications include immunohistochemistry, Western blotting, and immunofluorescence to unravel its physiological and pathological relevance. Further studies are needed to clarify its precise molecular mechanisms and clinical implications.

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