关键信息
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基因名
KDM6A
- 应用
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别名
(Histone demethylase UTX)(Ubiquitously-transcribed TPR protein on the X chromosome)(Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein)([histone H3]-trimethyl-L-lysine(27) demethylase 6A)
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种属
Human
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表达系统
E. coli
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标签
N- His & C- Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O15550
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表达区间
1095-1258aa
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分子量
26.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
KDM6A, a member of the lysine-specific demethylase (KDM) family, is known for its role in epigenetic regulation by demethylating histone H3 at lysine 27 (H3K27me3), which is crucial for gene activation. The gene encoding KDM6A is located on the X chromosome, and its mutations and dysregulation have been implicated in various cancers and developmental disorders, particularly in the context of tumorigenesis and X-linked intellectual disability. Research has shown that KDM6A is involved in cellular processes such as differentiation, proliferation, and response to environmental cues, making it a potential target for therapeutic interventions. Its unique expression patterns and functional roles in both embryonic development and adult tissues highlight the importance of KDM6A in maintaining cellular identity and homeostasis. Recent advances in recombinant protein technology have enabled the production of functional KDM6A protein, facilitating in-depth studies of its enzymatic activity, substrate specificity, and interaction with other cellular factors. This emerging research avenue aims to elucidate the mechanistic underpinnings of KDM6A's role in health and disease, paving the way for novel strategies in cancer treatment and regenerative medicine.
