| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Telomeric repeat-binding factor 2-interacting protein 1, TERF2-interacting telomeric protein 1, TRF2-interacting telomeric protein 1, Dopamine receptor-interacting protein 5, Repressor/activator protein 1 homolog, RAP1 homolog, hRap1, TERF2IP, DRIP5, RAP1 |
| Entrez GeneID | 54386 |
| WB Predicted band size | 44.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This TERF2IP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 349-378 amino acids from the C-terminal region of human TERF2IP. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TERF2IP抗体的3篇参考文献及其摘要内容：
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1. **文献名称**：*TERF2IP/RAP1 regulates telomere structure and protects chromosome ends*
**作者**：Sfeir et al. (2010)
**摘要**：该研究通过特异性TERF2IP抗体进行染色质免疫沉淀(ChIP)和免疫荧光实验，揭示TERF2IP通过结合端粒复合体(shelterin complex)维持端粒结构稳定性，防止染色体末端融合及DNA损伤反应激活。
2. **文献名称**：*Structural basis of telomere protection by the TERF2IP/RAP1 subunit of shelterin*
**作者**：Chen et al. (2012)
**摘要**：作者利用TERF2IP抗体进行蛋白质互作分析，结合X射线晶体学解析TERF2IP与端粒DNA结合的分子机制，阐明其如何通过构象变化调控端粒长度和端粒酶活性。
3. **文献名称**：*TERF2IP deficiency promotes oxidative stress-induced genomic instability in cancer cells*
**作者**：Martinez et al. (2018)
**摘要**：通过Western blot和免疫组化实验(使用TERF2IP特异性抗体)，研究发现TERF2IP缺失导致癌细胞端粒功能异常，加剧氧化应激下的DNA损伤和基因组不稳定性，提示其在肿瘤发生中的潜在作用。
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以上文献均聚焦于TERF2IP的功能机制，并涉及抗体在蛋白定位、互作及功能验证中的关键应用。
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