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Rabbit Polyclonal MAGOH Antibody

  • 中文名： MAGOH抗体
  • 别    名： Protein mago nashi homolog, MAGOH, MAGOHA
货号: IPDX31456
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesProtein mago nashi homolog, MAGOH, MAGOHA
Entrez GeneID4116
WB Predicted band size17.2kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis MAGOH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-74 amino acids from the Central region of human MAGOH.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于MAGOH抗体的3篇示例文献(内容为模拟概括，仅供参考)：

1. **《MAGOH作为结直肠癌预后生物标志物的研究》**

- 作者：Zhang等人(2018)

- 摘要：研究通过MAGOH抗体检测结直肠癌组织，发现MAGOH蛋白高表达与患者生存率降低相关，提示其可能作为预后不良的分子标志物。

2. **《MAGOH在胶质母细胞瘤中的功能及靶向治疗潜力》**

- 作者：Wang等人(2020)

- 摘要：利用MAGOH抗体进行免疫组化和基因沉默实验，证实MAGOH通过调控细胞周期促进肿瘤增殖，抗体阻断可抑制胶质母细胞瘤生长。

3. **《MAGOH在小鼠神经发育中的动态表达模式》**

- 作者：Chen等人(2021)

- 摘要：通过MAGOH抗体免疫荧光染色，揭示了MAGOH在小鼠胚胎神经管发育中的时空表达特征，提示其在外胚层分化中的关键作用。

建议通过PubMed或Web of Science检索最新文献，关键词："MAGOH antibody"、"MAGOH biomarker"或结合具体研究领域(如癌症、神经科学)。

背景信息

The MAGOH antibody is a crucial tool in studying the MAGOH protein, a core component of the exon junction complex (EJC), which plays essential roles in RNA processing, including mRNA splicing, nonsense-mediated decay (NMD), and translation regulation. MAGOH forms a heterodimer with its binding partner Y14 (RBM8A), and this complex is critical for maintaining RNA stability and ensuring accurate gene expression. Dysregulation of MAGOH has been implicated in various cancers, where its overexpression is linked to tumor progression, metastasis, and poor prognosis, particularly in glioblastoma, colorectal, and breast cancers. Researchers utilize MAGOH antibodies in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate its expression patterns, subcellular localization, and interactions within cellular pathways. These studies aim to elucidate MAGOH’s role in oncogenesis and its potential as a therapeutic target or diagnostic biomarker. Additionally, MAGOH antibodies contribute to understanding developmental biology, as EJC components are vital for embryogenesis and neural development. The antibody’s specificity and reliability are critical for distinguishing MAGOH from related EJC proteins, enabling precise mechanistic insights into RNA metabolism and disease-associated mutations. Overall, MAGOH antibodies serve as indispensable reagents in both basic research and translational studies exploring RNA biology and cancer mechanisms.

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