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Rabbit Polyclonal HN1 Antibody

  • 中文名： HN1抗体
  • 别    名： Hematological and neurological expressed 1 protein, Androgen-regulated protein 2, Hematological and neurological expressed 1 protein, N-terminally processed, HN1, ARM2
货号: IPDX31535
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 1/10-1/50 Human,Mouse,Rat
FCM 1/10-1/50 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesHematological and neurological expressed 1 protein, Androgen-regulated protein 2, Hematological and neurological expressed 1 protein, N-terminally processed, HN1, ARM2
Entrez GeneID51155
WB Predicted band size16.0kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis HN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-86 amino acids from the Central region of human HN1.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于HN1抗体的3篇示例文献(内容为虚构示例，仅作格式参考)：

1. **文献名称**: *HN1 Antibody Suppresses Hepatocellular Carcinoma Growth via Targeting STAT3 Signaling*

**作者**: Xu, L. et al.

**摘要**: 研究利用HN1特异性抗体抑制肝癌细胞增殖，证实HN1通过激活STAT3通路促进肿瘤生长，抗体干预可显著降低小鼠模型中肿瘤体积。

2. **文献名称**: *Mechanistic Role of HN1 in Prostate Cancer Metastasis and Antibody-based Therapy*

**作者**: Liu, Y. et al.

**摘要**: 发现HN1抗体通过阻断HN1与整合素β1的相互作用，抑制前列腺癌细胞的迁移和侵袭，为转移性癌症提供潜在治疗策略。

3. **文献名称**: *HN1 as a Novel Biomarker in Triple-Negative Breast Cancer: Validation by Immunohistochemistry*

**作者**: Wang, Q. et al.

**摘要**: 开发高特异性HN1单克隆抗体，证实HN1在三阴性乳腺癌组织中高表达，且与患者预后不良相关，提示其作为诊断标志物的潜力。

(注：以上文献为模拟内容，实际研究中请通过PubMed或学术数据库检索真实文献。)

背景信息

The HN1 antibody targets the HN1 (Hematological and Neurological Expressed 1) protein, a highly conserved molecule implicated in cellular proliferation, migration, and differentiation. First identified in hematopoietic and neural tissues, HN1 is encoded by the *JPT1* gene and contains a unique N-terminal immunoreceptor tyrosine-based activation motif (ITAM)-like domain and a C-terminal helical structure. While its exact physiological role remains under investigation, HN1 is linked to cytoskeletal dynamics, cell cycle regulation, and signaling pathways such as PI3K/Akt and Wnt/β-catenin. Overexpression of HN1 has been observed in multiple cancers, including breast, liver, and prostate cancers, where it correlates with tumor progression, metastasis, and poor prognosis. In cancer contexts, HN1 may enhance cell invasion by modulating actin polymerization or interacting with oncogenic kinases. Antibodies against HN1 are essential tools for detecting its expression in tissues or cell lines via immunohistochemistry, Western blotting, or flow cytometry. These reagents also enable functional studies to dissect HN1's role in normal and pathological processes. Recent research highlights HN1's potential as a therapeutic target or diagnostic biomarker, particularly in malignancies with aberrant HN1 activity. However, mechanistic insights into its molecular interactions and regulatory networks remain incomplete, necessitating further exploration.

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