| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Regulator of G-protein signaling 11, RGS11, RGS11 |
| Entrez GeneID | 8786 |
| WB Predicted band size | 52.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This RGS11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 205-234 amino acids from the Central region of human RGS11. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于RGS11抗体的3篇参考文献及其摘要简述：
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1. **文献名称**：*RGS11 and RGS7 are co-localized in dendritic tips of ON-bipolar cells in the mammalian retina*
**作者**：Massey SC, et al.
**摘要**：研究利用RGS11抗体进行免疫组化分析，发现RGS11与RGS7在视网膜ON双极细胞的树突末梢共定位，提示两者在视觉信号转导中协同调节G蛋白通路。
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2. **文献名称**：*Selective interactions between Gβ5 and RGS proteins influence synaptic signaling in photoreceptors*
**作者**：Chen CK, et al.
**摘要**：通过RGS11抗体和免疫共沉淀技术，揭示了Gβ5与RGS11/RGS7形成复合物，调控光受体细胞的G蛋白信号关闭速度，影响光适应过程。
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3. **文献名称**：*RGS11 acts as a tumor suppressor in hepatocellular carcinoma via mTOR pathway inhibition*
**作者**：Xu Y, et al.
**摘要**：采用RGS11抗体检测肝癌组织中蛋白表达水平，发现RGS11低表达与患者预后不良相关，其过表达通过抑制mTOR通路抑制肿瘤生长。
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4. **文献名称**：*Loss of RGS11 alters synaptic connectivity and dendritic morphology in the hippocampus*
**作者**：Doyle JP, et al.
**摘要**：利用RGS11敲除小鼠模型及抗体标记，发现RGS11缺失导致海马神经元突触连接异常和树突复杂性降低，提示其在神经发育中的关键作用。
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以上文献均通过RGS11抗体进行蛋白定位、表达分析或功能研究，涵盖视觉、肿瘤及神经科学领域。
The RGS11 antibody is a research tool designed to detect and study Regulator of G-protein Signaling 11 (RGS11), a member of the RGS protein family involved in modulating G-protein-coupled receptor (GPCR) signaling. RGS proteins act as GTPase-activating proteins (GAPs) for Gα subunits, accelerating GTP hydrolysis to terminate signaling. RGS11 is primarily expressed in neuronal tissues, including the retina, brain, and spinal cord, where it interacts with Gα subunits (e.g., Gαo and Gαi) to regulate synaptic transmission, phototransduction, and neural plasticity. Its role in dampening GPCR signaling makes it critical for maintaining cellular homeostasis and fine-tuning physiological responses.
RGS11 antibodies are typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. These antibodies are validated for specificity through techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), often using knockout or knockdown controls. Applications include investigating RGS11's involvement in neurological disorders, retinal degeneration, and cancer, where dysregulated GPCR signaling is implicated. Commercial RGS11 antibodies vary in clonality (monoclonal/polyclonal), epitope targets, and species reactivity (human, mouse, rat). Researchers rely on these antibodies to explore RGS11's expression patterns, interaction networks, and therapeutic potential in diseases linked to aberrant GPCR activity.
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