关键信息
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基因名
CCL21
- 应用
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别名
CCL21；SCYA21；C-C motif chemokine 21
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O00585
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表达区间
24-13aa
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氨基酸序列
SDGGAQDCCLKYSQRKIPAKVVRSYRKQEPSLGCSIPAILFLPRKRSQAE LCADPKELWVQQLMQHLDKTPSPQKPAQGCRKDRGASKTGKKGKGSKGCK RTERSQTPKGP
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分子量
12 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
CCL21, also known as chemokine (C-C motif) ligand 21, is a critical cytokine involved in immune system regulation and lymphocyte trafficking. It is predominantly expressed in secondary lymphoid organs like lymph nodes and the spleen, where it plays a pivotal role in guiding dendritic cells and naïve T cells to their sites of activation. The study of recombinant CCL21 proteins has gained prominence due to their potential applications in immunotherapy and vaccine development. Understanding the structure and function of CCL21 can aid in elucidating its involvement in various physiological and pathological processes, including autoimmune diseases, cancer progression, and viral infections. Researchers are increasingly interested in the recombinant expression of CCL21 to create therapeutics that can enhance immune responses or inhibit tumor growth by harnessing the body's natural defense mechanisms. Moreover, the ability to produce CCL21 in a controlled laboratory setting allows for in-depth studies of its interactions with receptors and other immune mediators. Overall, the research on recombinant CCL21 proteins holds significant promise for advancing our understanding of immune regulation and developing innovative therapeutic strategies.
