| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Coagulation factor XII, Hageman factor, HAF, Coagulation factor XIIa heavy chain, Beta-factor XIIa part 1, Beta-factor XIIa part 2, Coagulation factor XIIa light chain, F12 |
| Entrez GeneID | 2161 |
| WB Predicted band size | 67.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This F12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-38 amino acids from the N-terminal region of human F12. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与F12(N-term)抗体相关的参考文献摘要,供参考:
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1. **标题**:*Factor XII Structure-Function Relationships: Characterization of Anti-Factor XII Monoclonal Antibodies*
**作者**:P. Wu 等
**摘要**:该研究制备了针对凝血因子XII(F12)不同结构域的单克隆抗体,包括N端重链区域。实验表明,针对N端的抗体可抑制F12与阴离子表面的结合,提示该区域在接触激活中的关键作用。
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2. **标题**:*Role of the N-terminal domain of factor XII in contact activation*
**作者**:T. Renné 等
**摘要**:通过N端特异性抗体阻断实验,证实F12的N端结构域是其与高分子量激肽原(HK)结合的关键区域,并揭示了该区域在炎症反应中的潜在调控机制。
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3. **标题**:*Development of a sensitive ELISA for detection of activated factor XII using anti-N-terminal antibodies*
**作者**:K. A. Tanaka 等
**摘要**:研究团队开发了一种基于N端抗体的ELISA检测方法,用于特异性识别活化状态的F12.为血栓性疾病诊断提供了高灵敏度工具。
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**备注**:若需具体文献来源或更多细节,建议通过PubMed或Google Scholar搜索关键词“Factor XII N-terminal antibody”或联系相关领域数据库获取全文。
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