Cat: PA1000-585DB

Recombinant Human CETN2 Protein,His

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关键信息

  • 基因名

    CETN2

  • 应用

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    CETN2;CALT;CEN2;Centrin-2

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    His tag N-Terminus

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    P41208

  • 表达区间

    1-172aa

  • 氨基酸序列

    MASNFKKANMASSSQRKRMSPKPELTEEQKQEIREAFDLFDADGTGTIDVKELKVAMRALGFEPKKEEIKKMISEIDKEGTGKMNFGDFLTVMTQKMSEKDTKEEILKAFKLFDDDETGKISFKNLKRVAKELGENLTDEELQEMIDEADRDGDGEVSEQEFLRIMKKTSLY

  • 分子量

    35.7kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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背景信息

CETN2, or cetn2, is a gene that encodes for the neural-specific protein known as centrins. It is part of a larger family of centrin proteins that play crucial roles in cellular processes, including cell division, signaling, and the maintenance of cellular structure. Research on CETN2 has gained significant interest due to its involvement in various biological functions and its potential implications in diseases such as cancer, neurodegenerative disorders, and ciliopathies. Studies have shown that CETN2 is essential for the formation and stabilization of centrioles and cilia, organelles that are vital for proper cellular signaling and mechanosensation. The aberrant expression of CETN2 has been associated with disruptions in ciliary function, which can contribute to developmental defects and disease phenotypes. Given the importance of CETN2 in maintaining cellular integrity and function, understanding its structure and function could provide insights into its role in health and disease. Recent advances in recombinant protein technology have facilitated the production of CETN2, enabling researchers to investigate its biochemical properties, interactions with other proteins, and its potential as a therapeutic target. Thus, studying CETN2 as a recombinant protein not only deepens our understanding of its fundamental biology but also opens avenues for novel therapeutic strategies that could mitigate diseases linked to ciliary dysfunction and centrin-related pathways.

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