关键信息
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基因名
GPR15
- 应用
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别名
(Brother of Bonzo)(BoB)
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P49685
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表达区间
1-360aa
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分子量
43.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
GPR15, also known as G protein-coupled receptor 15, is a member of the GPCR family, which plays a critical role in various physiological processes by mediating cellular responses to extracellular signals. This receptor has garnered significant interest due to its involvement in immune responses, particularly its expression on certain immune cells such as T cells and its role in HIV infection. Research has indicated that GPR15 serves as a co-receptor for HIV, facilitating the virus’s entry into host cells, especially in the context of mucosal transmission. Furthermore, GPR15 has been implicated in the regulation of immune cell trafficking, influencing the distribution and function of lymphocytes within tissues. Understanding the structure and function of GPR15 through the study of recombinant proteins is essential for elucidating its role in both normal physiological functions and pathological conditions, including its dual role in immune modulation and viral pathogenesis. This knowledge could pave the way for novel therapeutic strategies targeting GPR15 to modulate immune responses or inhibit HIV infection, highlighting the importance of ongoing research in this area. The development of recombinant GPR15 proteins could facilitate high-throughput screening for potential therapeutic agents and contribute to the broader understanding of GPCR biology in health and disease.
