关键信息
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基因名
NOV
- 应用
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别名
NOV；IGFBP9；NOV；NOVH；CCN family member 3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P48745
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表达区间
28-357aa
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氨基酸序列
M+QVAATQRCP PQCPGRCPAT PPTCAPGVRA VLDGCSCCLV CARQRGESCS DLEPCDESSG LYCDRSADPS NQTGICTAVE GDNCVFDGVI YRSGEKFQPS CKFQCTCRDG QIGCVPRCQL DVLLPEPNCP APRKVEVPGE CCEKWICGPD EEDSLGGLTL AAYRPEATLG VEVSDSSVNC IEQTTEWTAC SKSCGMGFST RVTNRNRQCE MLKQTRLCMV RPCEQEPEQP TDKKGKKCLR TKKSLKAIHL QFKNCTSLHT YKPRFCGVCS DGRCCTPHNT KTIQAEFQCS PGQIVKKPVM VIGTCTCHTN CPKNNEAFLQ ELELKTTRGK M
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分子量
36.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
NOV (Nephroblastoma Overexpressed) is a member of the CCN family of proteins, which are secreted signaling molecules involved in various cellular processes, including cell adhesion, proliferation, and differentiation. Initially identified for its overexpression in nephroblastoma, a type of kidney cancer, NOV has since attracted attention for its broader involvement in multiple biological functions and diseases. Research has shown that NOV plays a critical role in tissue development, wound healing, and fibrosis by modulating the interactions between cells and the extracellular matrix. Its dysregulation has been implicated in several pathological conditions, including cancer, cardiovascular diseases, and chronic inflammatory disorders. Due to its unique structural features, which include a cysteine-rich domain and several other functional motifs, NOV has drawn interest for its potential therapeutic applications. Understanding the mechanisms by which NOV mediates its effects on cellular behavior could lead to innovative treatment strategies for diseases characterized by aberrant cellular signaling. Furthermore, NOV's potential as a biomarker for disease progression and prognosis highlights the importance of continued research into its functional roles and regulatory pathways.
