关键信息
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基因名
GP2b
- 应用
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别名
(Protein E)(Glycoprotein 2b)(Protein GP2b)(Gs)
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种属
PRRSV
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P0C6Y6
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表达区间
2-70aa
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分子量
13.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
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背景信息
GP2b, also known as glycoprotein IIb, is a critical component of the integrin complex found on platelets that plays a pivotal role in hemostasis and thrombosis. It forms a heterodimer with glycoprotein IIIa (GP3a) to create the integrin alphaIIbbeta3, which is essential for platelet aggregation. The importance of GP2b in hemostatic processes has made it a significant target for therapeutic intervention, particularly in conditions characterized by excessive platelet activation, such as acute coronary syndromes and other cardiovascular diseases. Research into GP2b has revealed its intricate involvement in platelet signaling pathways, mediating the cellular responses to various stimuli that promote clot formation. Additionally, GP2b has garnered attention in the context of biomarker discovery and personalized medicine, as variations or dysfunction in this protein can lead to bleeding disorders or thrombotic events. The development of recombinant GP2b proteins has opened avenues for both basic research and clinical applications, such as the design of novel antiplatelet therapies and diagnostic tools. Understanding the structure-function relationships of GP2b and its interactions with other platelet receptors remains a vibrant area of study, with implications for enhancing the efficacy and safety of various anticoagulant treatments. Overall, GP2b research is fundamental to advancing our knowledge of platelet biology and improving strategies for managing thrombotic diseases.
