关键信息
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基因名
KAT7
- 应用
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别名
KAT7；HBO1；HBOa；MYST2；Histone acetyltransferase KAT7
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O95251
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表达区间
1-611aa
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氨基酸序列
MPRRKRNAGSSSDGTEDSDFSTDLEHTDSSESDGTSRRSARVTRSSARLS QSSQDSSPVRNLQSFGTEEPAYSTRRVTRSQQQPTPVTPKKYPLRQTRSS GSETEQVVDFSDRETKNTADHDESPPRTPTGNAPSSESDIDISSPNVSHD ESIAKDMSLKDSGSDLSHRPKRRRFHESYNFNMKCPTPGCNSLGHLTGKH ERHFSISGCPLYHNLSADECKVRAQSRDKQIEERMLSHRQDDNNRHATRH QAPTERQLRYKEKVAELRKKRNSGLSKEQKEKYMEHRQTYGNTREPLLEN LTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTW YHSPYPEEYARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYR KGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVMTEAD NTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKV EEKVGSPERPLSDLGLISYRSYWKEVLLRYLHNFQGKEISIKEISQETAV NPVDIVSTLQALQMLKYWKGKHLVLKRQDLIDEWIAKEAKRSNSNKTMDP SCLKWTPPKGTYEFPEYSRDPTMYLALRNLILALWYTNCKEALTPQKCIP HIIVRGLVRIRCVQEVERILYFMTRKGLINTGVLTVAAGQHLLPKHYHNK SVLVVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVWDDKSFKGVVVG RGPQIVNGCINNPVALMCEQLGISMRKLGERCDLIQEGGRITDPTVDKRM DFHFNALLDVVSEWRKDKTLLQDVPLGEKIEEIYRAFVKESGIQFSELEG QVLQFHLSNLEYACGSSLHQVSARSWDHNEFFAQFAGDHTLLTPGYSTII EKLAEGLDIRLKSPVQSIDYTGDEVQVTTTDGMGHSAQKVLVTVPLAILQ RGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVQGADFFGH VPPSASQRGLFAVFYDMDSQQSVLMSVITGEAVASLRTMDDKQVLQQCMG ILRELFKEQEIPEPTKYFVTRWSTEPWIQMAYSFVKTFGSGEAYDIIAEE IQGTVFFAGEATNRHFPQTVTGAYLSGVREASKIAAF
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分子量
110 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
KAT7, also known as lysine acyltransferase 7, is an essential enzyme involved in histone modifications and the regulation of gene expression, playing a crucial role in epigenetic processes. It primarily functions to acetylate histone H3 at lysine 14 and is implicated in various cellular mechanisms, including transcriptional regulation, cell cycle progression, and differentiation. Aberrant expression or dysfunction of KAT7 has been associated with several diseases, including cancer, suggesting its potential as a therapeutic target. Research into KAT7's structure and function is vital for developing targeted therapies that can manipulate its activity for therapeutic benefit. The production of recombinant KAT7 protein allows for in-depth studies of its enzymatic properties, interactions with various substrates, and regulatory mechanisms. Furthermore, understanding the kinetics of KAT7, as well as its role in establishing and maintaining chromatin architecture, can provide insights into broader epigenetic landscapes and their influence on cellular behavior. The exploration of KAT7's role within different biological contexts, including development and disease pathology, has the potential to unveil novel strategies for intervention in epigenetic disorders and promote advancements in precision medicine.
