关键信息
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基因名
Syt2
- 应用
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别名
(Synaptotagmin II)(SytII)
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种属
Rat
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P29101
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表达区间
1-422aa
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分子量
48.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
Syt2, or Synaptotagmin 2, is a calcium-sensor protein primarily found in presynaptic terminals of neurons and is integral to neurotransmitter release. The protein functions as a crucial mediator in the synaptic transmission process, facilitating exocytosis upon calcium influx. Given its pivotal role in synaptic function, Syt2 has garnered significant attention in neuroscience research, particularly in understanding synaptic plasticity, learning, and memory processes. Abnormalities in Syt2 expression or function have been linked to various neurodegenerative diseases and psychiatric disorders, making it a potential target for therapeutic interventions. Additionally, the study of Syt2 and its structural and functional properties through recombinant protein techniques can provide insights into the mechanisms of synaptic vesicle fusion and release. By employing advanced biophysical methods and genetic manipulations, researchers aim to elucidate the precise roles of Syt2 in synaptic dynamics, furthering our comprehension of neuronal communication and potential implications for treating synaptic dysfunctions in neurological diseases. Understanding Syt2's interactions with other synaptic proteins and its calcium-binding properties is essential for uncovering its complete functional profile and relevance in synaptic health and disease.
