关键信息
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基因名
GPC2
- 应用
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别名
GPC2；Glypican-2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8N158
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表达区间
24-554aa
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氨基酸序列
SEAKVTR SCAETRQVLG ARGYSLNLIP PALISGEHLR VCPQEYTCCS SETEQRLIRE TEATFRGLVE DSGSFLVHTL AARHRKFDEF FLEMLSVAQH SLTQLFSHSY GRLYAQHALI FNGLFSRLRD FYGESGEGLD DTLADFWAQL LERVFPLLHP QYSFPPDYLL CLSRLASSTD GSLQPFGDSP RRLRLQITRT LVAARAFVQG LETGRNVVSE ALKVPVSEGC SQALMRLIGC PLCRGVPSLM PCQGFCLNVV RGCLSSRGLE PDWGNYLDGL LILADKLQGP FSFELTAESI GVKISEGLMY LQENSAKVSA QVFQECGPPD PVPARNRRAP PPREEAGRLW SMVTEEERPT TAAGTNLHRL VWELRERLAR MRGFWARLSL TVCGDSRMAA DASLEAAPCW TGAGRGRYLP PVVGGSPAEQ VNNPELKVDA SGPDVPTRRR RLQLRAATAR MKTAALGHDL DGQDADEDAS GSGGGQQYAD DWMAGAVAPP ARPPRPPYPP RRDGSGGKGG GGSARYNQGR SRSG
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
GPC2 (glypican-2) is an heparan sulfate proteoglycan that plays a significant role in cell proliferation, differentiation, and tumorigenesis, particularly in the context of neurodevelopmental processes. Its expression is notably elevated in various pediatric tumors, including neuroblastoma, which has prompted extensive research into GPC2 as a therapeutic target. The study of GPC2 recombinant proteins has become increasingly important, as these proteins can be utilized in immunotherapy and targeted treatment approaches. By generating GPC2 recombinant proteins, researchers aim to enhance the understanding of GPC2's biological functions and its interactions with cells and the extracellular matrix. These recombinant proteins can be used to develop specific antibodies or assess potential therapeutic vaccines, which may significantly improve treatment outcomes for patients with tumors expressing high levels of GPC2. Additionally, the investigation of GPC2's role in tumor microenvironments could reveal new insights into tumor progression and metastasis, aiding in the design of innovative intervention strategies. Overall, the research on GPC2 recombinant proteins is paving the way for novel diagnostic and therapeutic avenues in cancer treatment, particularly for aggressive childhood cancers, thereby enhancing the prospects for more effective and personalized medical care.
