关键信息
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基因名
GPR173
- 应用
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别名
GPR173; SREB3; Probable G-protein coupled receptor 173; Super conserved receptor expressed in brain 3
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NS66
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表达区间
1-373aa
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氨基酸序列
MANTTGEPEEVSGALSPPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYFLLDLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVTRYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHRYFKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQAAANWIAGFGRGPMPPTLLGIRQNGHAASRRLLGMDEVKGEKQLGRMFYAITLLFLLLWSPYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHAPCWGTGGAPAPREPYCVM
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分子量
67.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
GPR173, also known as the "G protein-coupled receptor 173," has garnered significant attention in recent years due to its potential roles in various physiological and pathological processes. This orphan receptor, which has a yet undefined ligand, is predominantly expressed in the brain and immune tissues, suggesting its involvement in neuromodulation and immune responses. Research indicates that GPR173 may play a crucial role in regulating cellular activities such as proliferation, migration, and differentiation, particularly in the context of neurodevelopment and immune regulation. Understanding the molecular mechanisms of GPR173 has implications for various diseases, including neurological conditions and immune-related disorders. The study of recombinant GPR173 proteins serves as a critical step in elucidating its biological functions and therapeutic potential. By generating these proteins, researchers can investigate the receptor's signaling pathways, ligand interaction, and effects on cellular responses in vitro and in vivo. The characterization of GPR173 through recombinant technology not only enhances our understanding of its physiological roles but also opens avenues for developing targeted therapies aimed at modulating its activity in disease contexts. Thus, the investigation of GPR173 recombinant proteins holds promise for advancing both basic research and clinical applications, providing insights into novel therapeutic strategies for conditions associated with dysregulated GPR173 signaling.
