关键信息
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基因名
GPR34
- 应用
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别名
GPR34; Probable G-protein coupled receptor 34
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UPC5
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表达区间
1-381aa
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氨基酸序列
MRSHTITMTTTSVSSWPYSSHRMRFITNHSDQPPQNFSATPNVTTCPMDEKLLSTVLTTSYSVIFIVGLVGNIIALYVFLGIHRKRNSIQIYLLNVAIADLLLIFCLPFRIMYHINQNKWTLGVILCKVVGTLFYMNMYISIILLGFISLDRYIKINRSIQQRKAITTKQSIYVCCIVWMLALGGFLTMIILTLKKGGHNSTMCFHYRDKHNAKGEAIFNFILVVMFWLIFLLIILSYIKIGKNLLRISKRRSKFPNSGKYATTARNSFIVLIIFTICFVPYHAFRFIYISSQLNVSSCYWKEIVHKTNEIMLVLSSFNSCLDPVMYFLMSSNIRKIMCQLLFRRFQGEPSRSESTSEFKPGYSLHDTSVAVKIQSSSKST
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分子量
70.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
GPR34, a member of the G protein-coupled receptor (GPCR) family, has garnered significant research interest due to its unique expression patterns and potential roles in various physiological and pathological processes. Initially identified in immune cells, GPR34 has been implicated in modulating inflammatory responses, making it a candidate for therapeutic exploration in autoimmune diseases. Recent studies suggest that GPR34 may also play a role in the central nervous system, influencing neuroinflammation and neurodegenerative disorders. The receptor's natural ligands and downstream signaling pathways remain largely unexplored, presenting a gap in understanding its functional mechanisms. To address this, researchers have developed recombinant GPR34 proteins to facilitate structural and functional characterization. These studies aim to elucidate the receptor's binding affinities, activation states, and interaction with various ligands, paving the way for potential drug development. As GPCRs are commonly targeted in pharmacology, insights gained from GPR34 research may contribute to novel therapeutic strategies for treating conditions linked to immune dysregulation and neuroinflammation. The continued investigation of GPR34 presents a promising avenue for understanding its biological significance and therapeutic potential in diverse medical fields.
