关键信息
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基因名
GRPEL2
- 应用
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别名
GrpE like 2; mitochondrial; GrpE protein homolog 2; GRPE2_HUMAN; GRPEL 2; Grpel2; mitochondrial; Mt GrpE#2; Mt-GrpE#2
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8TAA5
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表达区间
1-225aa
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氨基酸序列
MAVRSLWAGRLRVQRLLAWSAAWESKGWPLPFSTATQRTAGEDCRSEDPPDELGPPLAERALRVKAVKLEKEVQDLTVRYQRAIADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTTECISEESEPEDQKLTLEKVFRGLLLLEAKLKSVFAKHGLEKLTPIGDKYDPHEHELICHVPAGVGVQPGTVALVRQDGYKLHGRTIRLARVEVAVESQRRL
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分子量
51.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
GRPEL2 (GTPase-Related Protein with EF-Hand Motifs 2) is a significant member of the molecular chaperone family, primarily involved in the mitochondrial protein import and folding processes. Understanding the function of GRPEL2 is crucial due to its role in maintaining mitochondrial homeostasis and its potential implications in various diseases, particularly those related to mitochondrial dysfunction. Research into GRPEL2 has gained traction as scientists seek to elucidate its mechanism of action, interactions with other proteins, and its role in cellular stress responses. Recent studies have highlighted the importance of GRPEL2 in facilitating the proper folding and assembly of mitochondrial proteins, specifically in the context of the mitochondrial import machinery. Additionally, its involvement in the regulation of apoptosis and cellular metabolism adds further interest to its study, linking it to broader metabolic diseases and neurodegenerative conditions. Given the increasing prevalence of mitochondrial-related disorders, GRPEL2 presents a promising target for therapeutic intervention, prompting research aimed at developing strategies to modulate its function. The ongoing exploration of GRPEL2 through recombinant protein studies, structural analyses, and interaction mapping will contribute significantly to our understanding of mitochondrial biology and the development of novel treatment approaches.
