关键信息
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基因名
H2AFY2
- 应用
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别名
Core histone macro H2A2.2; Core histone macro-H2A.2; Core histone macroH2A2.2; H2A histone family member Y2; H2AFY2; H2AW_HUMAN; Histone macroH2A2; Macro H2A.2; Macro H2A2; MacroH2A.2; MacroH2A2; mH2A2
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9P0M6
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表达区间
1-372aa
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氨基酸序列
MSGRSGKKKMSKLSRSARAGVIFPVGRLMRYLKKGTFKYRISVGAPVYMAAVIEYLAAEILELAGNAARDNKKARIAPRHILLAVANDEELNQLLKGVTIASGGVLPRIHPELLAKKRGTKGKSETILSPPPEKRGRKATSGKKGGKKSKAAKPRTSKKSKPKDSDKEGTSNSTSEDGPGDGFTILSSKSLVLGQKLSLTQSDISHIGSMRVEGIVHPTTAEIDLKEDIGKALEKAGGKEFLETVKELRKSQGPLEVAEAAVSQSSGLAAKFVIHCHIPQWGSDKCEEQLEETIKNCLSAAEDKKLKSVAFPPFPSGRNCFPKQTAAQVTLKAISAHFDDSSASSLKNVYFLLFDSESIGIYVQEMAKLDAK
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分子量
66.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
H2AFY2, also known as H2A.z or histone variant H2A.F/Z, is a core component of the histone family that plays a crucial role in the regulation of gene expression and chromatin dynamics. Its unique properties set it apart from canonical histone H2A, enabling it to form distinct nucleosomal structures that influence transcriptional activation and repression. Research on H2AFY2 has garnered significant attention due to its involvement in various cellular processes, including DNA repair, replication, and epigenetic modifications. Notably, H2AFY2 is implicated in several biological pathways linked to developmental processes and diseases, including cancer. As a result, understanding the biochemical properties and functional mechanisms of H2AFY2 is essential for deciphering its role in cellular homeostasis and the pathology of diseases. Recent advancements in recombinant protein technology have facilitated the production and characterization of H2AFY2, allowing researchers to investigate its structural features and interactions with other nuclear proteins. This approach has yielded insights into the importance of H2AFY2 in chromatin remodeling and its potential as a therapeutic target. Overall, the study of H2AFY2 recombinant protein contributes to our understanding of histone variants and their complex roles in gene regulation and cellular physiology.
