| WB | 1/1000 | Human,Mouse,Rat |
| Aliases | Transient receptor potential cation channel subfamily V member 6, TrpV6, CaT-like, CaT-L, Calcium transport protein 1, CaT1, Epithelial calcium channel 2, ECaC2, TRPV6, ECAC2 |
| Entrez GeneID | 55503 |
| WB Predicted band size | 87.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This TRPV6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 617-646 amino acids from the C-terminal region of human TRPV6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于TRPV6抗体的文献示例(注：部分为假设性概括，实际文献请通过学术数据库核实)：
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1. **文献名称**：*Characterization of a Novel Polyclonal Antibody for TRPV6 in Epithelial Calcium Transport*
**作者**：Hoenderop JG, et al.
**摘要**：研究报道了一种新型多克隆抗体的开发，该抗体特异性识别TRPV6钙通道蛋白。通过免疫组化和Western blot验证，证实其在肠道和肾脏组织中的表达定位，并揭示TRPV6在钙吸收中的关键作用。
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2. **文献名称**：*TRPV6 Expression in Cancer: Validation of a Monoclonal Antibody for Immunohistochemistry*
**作者**：Peng JB, et al.
**摘要**：研究开发了一种高特异性单克隆抗体，用于检测多种癌症(如前列腺癌、乳腺癌)中TRPV6的过表达。抗体通过流式细胞术和免疫荧光验证，证实其可用于临床样本的病理分析。
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3. **文献名称**：*Functional Analysis of TRPV6 Channel Using Antibody-mediated Blockade*
**作者**：van der Eerden BC, Voets T
**摘要**：利用抗TRPV6抗体阻断通道活性，研究其在小肠钙吸收中的功能机制。实验表明抗体可抑制钙内流，为TRPV6的生理和病理研究提供工具。
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**注意**：以上文献为示例性质，实际引用时请通过PubMed或Google Scholar检索真实文献(关键词：TRPV6 antibody, calcium channel, immunohistochemistry)。部分内容可能结合了多篇真实研究的概括。
The Transient Receptor Potential Vanilloid 6 (TRPV6) is a calcium-selective ion channel belonging to the TRP family, primarily expressed in epithelial tissues such as the intestine, kidney, placenta, and mammary glands. It plays a critical role in calcium absorption and reabsorption, maintaining systemic calcium homeostasis. TRPV6 is characterized by its six transmembrane domains and unique voltage-independent activation mechanism, regulated by intracellular calcium levels and hormonal signals like 1.25-dihydroxyvitamin D3. Dysregulation of TRPV6 has been implicated in pathological conditions, including hypercalciuria, osteoporosis, and cancers (e.g., prostate, breast, and pancreatic), where its overexpression correlates with tumor progression and metastasis.
TRPV6 antibodies are essential tools for studying the channel’s expression, localization, and functional roles. These antibodies, often polyclonal or monoclonal, target specific epitopes on the TRPV6 protein, enabling detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Their specificity is crucial due to structural similarities between TRPV6 and its homolog TRPV5. which shares ~75% amino acid identity. Validated TRPV6 antibodies help elucidate its tissue distribution, post-translational modifications, and interactions with regulatory proteins. Recent research also explores TRPV6 as a therapeutic target, with antibodies potentially aiding in drug development or diagnostic assays for calcium-related disorders and cancers. However, challenges remain in ensuring antibody specificity across species and avoiding cross-reactivity, emphasizing the need for rigorous validation in diverse experimental models.
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