| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | STYK1, NOK, Protein PK-unique, SuRTK106, Tyrosine-protein kinase STYK1 |
| Entrez GeneID | 55359; |
| WB Predicted band size | 47kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | A synthesized peptide derived from human STYK1/NOK (Phospho-Tyr327) |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于STYK1/NOK (Phospho-Tyr327)抗体的参考文献示例(注：文献为虚构示例，仅作格式参考)：
1. **"STYK1 Phosphorylation at Tyr327 Promotes Tumor Metastasis in Triple-Negative Breast Cancer"**
- **作者**: Zhang, Y. et al.
- **摘要**: 研究揭示了STYK1在Tyr327位点的磷酸化通过激活MAPK信号通路，增强乳腺癌细胞的迁移和侵袭能力，该抗体用于检测患者组织样本中磷酸化STYK1的表达水平与预后相关性。
2. **"NOK/STYK1 Tyrosine 327 Phosphorylation Regulates EGFR Interaction in Lung Adenocarcinoma"**
- **作者**: Liu, X. et al.
- **摘要**: 通过免疫共沉淀和Western blot分析，证实Tyr327磷酸化的STYK1与EGFR形成复合物，促进肺癌细胞增殖，抗体的特异性验证为靶向治疗提供了实验依据。
3. **"Phosphorylated STYK1 as a Biomarker for Ovarian Cancer Progression"**
- **作者**: Chen, L. et al.
- **摘要**: 利用Phospho-Tyr327抗体进行免疫组化分析，发现STYK1磷酸化水平与卵巢癌患者化疗耐药性显著相关，提示其作为潜在治疗靶点的价值。
4. **"Structural Basis of STYK1 Activation via Phosphorylation at Tyr327"**
- **作者**: Wang, H. et al.
- **摘要**: 通过晶体学分析和体外激酶实验，阐明Tyr327磷酸化对STYK1激酶活性的调控机制，抗体用于验证磷酸化状态对蛋白质构象的影响。
(注：以上文献为模拟内容，实际研究中请通过PubMed、Google Scholar等平台检索真实文献。)
The STYK1/NOK (Phospho-Tyr327) antibody is designed to detect the phosphorylated form of STYK1 (serine/threonine/tyrosine kinase 1), also known as novel oncogenic kinase (NOK), at tyrosine residue 327. STYK1 is a transmembrane receptor tyrosine kinase-like protein implicated in regulating cell proliferation, apoptosis, and tumorigenesis. Unlike classical receptor tyrosine kinases, STYK1 lacks an extracellular ligand-binding domain but retains intracellular kinase activity. Its phosphorylation at Tyr327 is critical for kinase activation and downstream signaling, often linked to pathways like MAPK/ERK and PI3K/AKT, which drive cancer progression.
Research highlights STYK1 overexpression in various cancers, including breast, lung, and gastric cancers, where it correlates with poor prognosis. The Phospho-Tyr327 antibody serves as a tool to study STYK1 activation status in cancer models, enabling insights into its role in oncogenic signaling and metastasis. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess phosphorylation-dependent interactions or therapeutic responses. Studies also explore its potential as a biomarker or therapeutic target, particularly in tumors with aberrant STYK1 activity. This antibody aids in elucidating mechanisms underlying STYK1-driven malignancy and evaluating targeted therapies.
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