| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/100-1/500 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | armadillo repeat containing 6; |
| Entrez GeneID | 93436; |
| WB Predicted band size | 54kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from internal of human ARMC6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ARMC6抗体的3篇参考文献的简要总结(注：文献为模拟示例，实际需根据具体研究补充)：
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1. **文献名称**: *ARMC6 regulates ciliogenesis and Hedgehog signaling through interaction with CEP164*
**作者**: Zhang L, et al. (2021)
**摘要**: 本研究利用ARMC6特异性抗体，发现ARMC6通过与纤毛基体蛋白CEP164相互作用，调控纤毛形成并影响Hedgehog信号通路。敲除ARMC6导致纤毛结构缺陷，提示其在发育疾病中的潜在作用。
2. **文献名称**: *ARMC6 modulates Wnt/β-catenin signaling in colorectal cancer progression*
**作者**: Tanaka K, et al. (2019)
**摘要**: 通过ARMC6抗体进行免疫沉淀和Western blot分析，发现ARMC6在结直肠癌中高表达，并通过稳定β-catenin蛋白增强Wnt信号通路，促进肿瘤侵袭转移。
3. **文献名称**: *A novel ARMC6 antibody-based assay for diagnosing primary ciliary dyskinesia*
**作者**: Müller A, et al. (2022)
**摘要**: 开发了一种高灵敏度的ARMC6抗体检测方法，用于原发性纤毛运动障碍(PCD)的临床诊断。研究发现ARMC6表达水平与患者纤毛运动功能显著相关。
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**注**：以上文献为示例，实际研究中需查阅PubMed、Google Scholar等数据库获取具体文献信息。ARMC6研究多集中于纤毛生物学、癌症及遗传性疾病领域。
ARMC6 (Armadillo Repeat-Containing Protein 6) is a member of the ARMC protein family, characterized by the presence of Armadillo (ARM) repeat domains that mediate protein-protein interactions. While the precise biological role of ARMC6 remains under investigation, it is implicated in diverse cellular processes, including cytoskeletal organization, intracellular signaling, and cilia function. Studies suggest its interaction with components of the Hippo signaling pathway, which regulates cell proliferation and organ size, and its potential involvement in ciliogenesis, a process critical for sensory and developmental functions.
ARMC6 antibodies are immunological tools designed to detect and study the expression, localization, and function of the ARMC6 protein. These antibodies are commonly used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to analyze ARMC6 expression patterns in tissues or cultured cells. Research utilizing ARMC6 antibodies has explored its potential roles in diseases, including cancers and ciliopathies—genetic disorders linked to defective cilia. For example, altered ARMC6 expression has been observed in certain tumors, suggesting possible regulatory roles in tumorigenesis or metastasis.
Despite progress, the functional mechanisms of ARMC6 remain partially unresolved. ARMC6 antibodies thus serve as critical reagents for elucidating its interaction networks, post-translational modifications, and relevance to human health. Commercial and custom-generated ARMC6 antibodies vary in specificity and validation, requiring careful optimization for experimental reproducibility. Ongoing studies aim to clarify ARMC6's contributions to cellular homeostasis and disease, highlighting its emerging significance in molecular and clinical research.
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