| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Brain protein 44; |
| Entrez GeneID | 25874; |
| WB Predicted band size | 14kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human BRP44. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于BRP44抗体的3篇虚构参考文献示例，供参考：
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1. **文献名称**：*BRP44: A Novel Mitochondrial Protein Involved in Respiratory Chain Assembly*
**作者**：Smith J, et al.
**摘要**：本研究利用特异性BRP44抗体，通过免疫印迹和免疫荧光技术，证实BRP44定位于线粒体内膜，并参与调节呼吸链复合物III的组装过程。敲除BRP44导致线粒体功能异常。
2. **文献名称**：*BRP44 Antibody-Based Detection of Oxidative Stress Markers in Neurodegenerative Disease*
**作者**：Lee H, et al.
**摘要**：通过BRP44抗体检测阿尔茨海默病模型小鼠脑组织，发现BRP44表达水平与氧化应激标志物呈正相关，提示其可能作为神经退行性病变的生物标志物。
3. **文献名称**：*Characterization of BRP44 Interactions Using Co-Immunoprecipitation*
**作者**：Garcia R, et al.
**摘要**：利用BRP44抗体进行免疫共沉淀实验，发现BRP44与伴侣蛋白HSP60存在直接相互作用，可能参与线粒体蛋白折叠质量控制机制。
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注：以上文献为假设性示例，实际研究中请通过学术数据库(如PubMed)检索真实文献。
BRP44 (Brain Protein 44), also known as BRP44 or C6orf130. is a conserved mitochondrial protein implicated in cellular energy metabolism and respiratory chain function. Initially identified through genomic and proteomic studies, BRP44 is associated with mitochondrial Complex III (ubiquinol-cytochrome c reductase), a key component of the electron transport chain. It is believed to play a role in Complex III assembly or stability, though its precise molecular mechanisms remain under investigation. The protein is ubiquitously expressed, with higher levels observed in tissues with elevated metabolic demands, such as the brain, heart, and skeletal muscle.
BRP44 antibodies are primarily used in research to study mitochondrial biology, oxidative phosphorylation, and diseases linked to mitochondrial dysfunction, such as neurodegenerative disorders, cardiomyopathies, and cancer. These antibodies enable the detection of BRP44 via techniques like Western blotting, immunofluorescence, and immunohistochemistry, aiding in the exploration of its localization, expression patterns, and interactions. Recent studies suggest BRP44 may serve as a biomarker for mitochondrial health or a therapeutic target in metabolic syndromes. Its conservation across species underscores its fundamental role in cellular energetics, driving ongoing interest in its functional characterization.
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