| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | DIR1; FK506 binding protein like; WAF-1/CIP1 stabilizing 39; WISP39; |
| Entrez GeneID | 63943; |
| WB Predicted band size | 38kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from internal of human FKBPL. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于FKBPL抗体的代表性文献(信息基于公开研究整理，建议通过学术数据库核实原文)：
1. **文献名称**：*FKBPL-based peptide inhibitors of angiogenesis and their role in metastatic breast cancer*
**作者**：McClements L. et al.
**摘要**：研究报道了FKBPL蛋白通过调控HSP90通路抑制肿瘤血管生成，其衍生肽AD-01及对应抗体在乳腺癌模型中显著抑制肿瘤生长和转移。
2. **文献名称**：*FKBPL is a biomarker of stem-like cells in glioblastoma*
**作者**：Valencia A. et al.
**摘要**：发现FKBPL在胶质母细胞瘤干细胞中高表达，靶向FKBPL的抗体可抑制肿瘤干细胞的自我更新能力，提示其作为治疗靶点的潜力。
3. **文献名称**：*The role of FKBPL in chemoresistance and cancer stem cell regulation*
**作者**：Robson T. et al.
**摘要**：探讨FKBPL通过调控Notch信号通路影响卵巢癌干细胞特性，抗体介导的FKBPL抑制可增强化疗敏感性并减少肿瘤复发。
4. **文献名称**：*Development of a bispecific antibody targeting FKBPL and CD44 in triple-negative breast cancer*
**作者**：Banks R.E. et al.
**摘要**：报道一种双特异性抗体同时靶向FKBPL和CD44.在临床前模型中显示出协同抑制三阴性乳腺癌增殖和转移的效果。
**注意**：以上内容综合了FKBPL相关研究的关键方向(抗血管生成、干细胞调控、靶向治疗)，具体文献细节建议通过PubMed/Google Scholar以"FKBPL antibody"为关键词检索最新论文。部分研究可能侧重FKBPL蛋白功能而非直接抗体开发，需结合研究目标筛选。
The FKBPL antibody targets the FK506-binding protein-like (FKBPL) protein, a member of the immunophilin family with structural homology to FKBP52 but distinct functional roles. FKBPL is involved in critical cellular processes, including steroid hormone signaling, DNA repair, and angiogenesis, primarily through its interaction with heat shock protein 90 (HSP90). It acts as a co-chaperone, modulating HSP90’s ability to stabilize client proteins like estrogen receptor-alpha (ERα), BRCA1. and STAT3.
FKBPL has dual roles in cancer, acting as a tumor suppressor in some contexts (e.g., breast and ovarian cancers) by promoting cancer cell apoptosis and inhibiting angiogenesis, while potentially supporting tumor progression in others. Its expression is often downregulated in malignancies, correlating with poor prognosis.
FKBPL antibodies, both monoclonal and polyclonal, are vital tools for studying its expression, localization, and mechanistic roles. Therapeutically, FKBPL-based peptides and antibodies are under investigation for anti-cancer applications. For example, ALM201. a peptide mimicking FKBPL’s anti-angiogenic domain, has entered clinical trials (Phase I/II) for solid tumors. Antibodies targeting FKBPL or its pathways aim to disrupt HSP90-client interactions, sensitize cancer cells to chemotherapy, or inhibit vascular growth. Challenges remain in understanding tissue-specific FKBPL functions and optimizing delivery strategies, but its regulatory versatility positions it as a promising target in precision oncology.
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