| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CRS2; FPP; Homeobox protein Hox-8; Homeobox protein MSX-2; HOX8 |
| Entrez GeneID | 4488; |
| WB Predicted band size | 29kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from Internal of human MSX2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MSX2抗体的3篇参考文献概览(基于公开研究整理，非真实文献，仅示例格式)：
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1. **文献名称**: *"MSX2 Antibody Characterization in Craniofacial Development Studies"*
**作者**: Satokata I., Maas R.
**摘要**: 研究通过免疫组化方法验证MSX2抗体在小鼠胚胎颅面发育中的特异性，发现MSX2在颅缝闭合中起关键作用，抗体染色显示其在成骨前体细胞中高表达，为颅骨畸形机制提供依据。
2. **文献名称**: *"Role of MSX2 in Breast Cancer Metastasis: An Antibody-Based Analysis"*
**作者**: Han H. et al.
**摘要**: 利用MSX2抗体进行Western blot和免疫荧光实验，证明MSX2在乳腺癌细胞中过表达，促进上皮-间质转化(EMT)，提示其作为转移标志物的潜在价值。
3. **文献名称**: *"MSX2 Antibody Application in Osteogenic Differentiation of Stem Cells"*
**作者**: Jia S. et al.
**摘要**: 研究通过MSX2抗体检测间充质干细胞分化中MSX2蛋白的动态变化，发现其通过抑制Wnt/β-catenin通路延缓成骨分化，为骨再生医学提供新靶点。
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如需真实文献，建议在PubMed或Google Scholar检索关键词“MSX2 antibody application”或“MSX2 immunohistochemistry”获取具体研究。
The MSX2 antibody is a research tool used to detect the MSX2 protein, a homeodomain-containing transcription factor encoded by the *MSX2* gene. MSX2 belongs to the muscle segment homeobox (MSX) family, homologous to the *Drosophila* msh (muscle segment homeobox) gene. It plays critical roles in embryonic development, including craniofacial morphogenesis, limb patterning, and organogenesis by regulating cell proliferation, differentiation, and apoptosis. MSX2 is particularly noted for its involvement in osteoblast differentiation and skeletal development, with mutations linked to craniosynostosis (premature skull fusion) and parietal foramina defects.
In research, MSX2 antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study protein expression and localization in tissues or cultured cells. These antibodies help elucidate MSX2's role in developmental biology, cancer (e.g., breast and colorectal tumors), and genetic disorders. Commercial MSX2 antibodies are typically raised against specific epitopes, such as the N-terminal or C-terminal regions, and validated for specificity using knockout controls.
Understanding MSX2's regulatory mechanisms via antibody-based studies contributes to insights into developmental defects, tissue regeneration, and potential therapeutic targets. Its dual role as a transcriptional repressor and context-dependent activator underscores its complexity in developmental and pathological processes.
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