| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Homeobox protein Nkx-2.4; Homeobox protein NKX2.4; Homeobox protein NK-2 homolog D; |
| Entrez GeneID | 644524; |
| WB Predicted band size | 40kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human NKX24. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下提供的参考文献信息为模拟示例，因实际文献可能有限，建议通过学术数据库(如PubMed、Google Scholar)核实具体研究内容：
1. **标题**：*NKX2-4 as a Novel Marker in Thyroid Cancer: Expression Analysis Using a Specific Polyclonal Antibody*
**作者**：Smith A, et al.
**摘要**：本研究开发了一种针对NKX2-4蛋白的多克隆抗体，并通过免疫组化证实其在甲状腺癌组织中特异性高表达，提示其可能作为甲状腺癌诊断的潜在标志物。
2. **标题**：*Functional Role of NKX2-4 in Lung Development: Insights from Antibody-Based Knockdown Models*
**作者**：Chen L, et al.
**摘要**：利用抗NKX2-4抗体进行蛋白质定位和功能阻断实验，发现NKX2-4在小鼠胚胎肺上皮细胞分化中起关键作用，缺失会导致肺泡发育异常。
3. **标题**：*Cross-Species Conservation of NKX2-4 Epitopes: Validation of a Commercial Antibody in Zebrafish*
**作者**：Garcia R, et al.
**摘要**：验证某商业化NKX2-4抗体在斑马鱼模型中的交叉反应性，证实其适用于Western blot和免疫荧光，为进化发育生物学研究提供工具。
4. **标题**：*NKX2-4 Antibody Application in Pancreatic Cell Lineage Tracing*
**作者**：Kim H, et al.
**摘要**：通过NKX2-4抗体标记，揭示其在胰腺祖细胞中的动态表达模式，为糖尿病细胞治疗研究提供新靶点。
**注意**：以上文献为假设案例，实际研究中NKX2-4相关抗体文献较少，建议结合具体研究领域(如转录因子、发育生物学)扩大检索范围。
The NKX2-4 antibody is a tool used to detect NKX2-4. a transcription factor belonging to the NKX homeobox family. NKX2-4 (NK2 Homeobox 4) is encoded by the NKX2-4 gene and shares structural homology with other NKX proteins, featuring a conserved homeodomain critical for DNA binding and transcriptional regulation. While its exact biological roles remain less characterized compared to other family members (e.g., NKX2-1 in thyroid development or NKX2-5 in heart formation), NKX2-4 is implicated in developmental processes, potentially influencing organogenesis in tissues like the thyroid, lung, or nervous system. Studies suggest it may regulate gene networks involved in cell differentiation and tissue patterning.
NKX2-4 antibodies are typically developed in hosts like rabbits or mice, often validated for specificity in applications such as Western blotting, immunohistochemistry, or immunofluorescence. These antibodies enable researchers to map NKX2-4 expression patterns in tissues or disease models, aiding investigations into its physiological or pathological roles. While direct links to human diseases are not yet well-established, dysregulation of NKX2 family proteins is associated with congenital defects and cancers, positioning NKX2-4 as a potential biomarker or therapeutic target. Ongoing research aims to clarify its interactions and functional significance in development and disease.
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