| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Leucine-rich repeat-containing protein 41; Protein Muf1; |
| Entrez GeneID | 10489; |
| WB Predicted band size | 80kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | Synthesized peptide derived from internal of human LRRC41. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是3篇关于LRRC41抗体的假设参考文献示例(注：文献为虚构，仅供格式参考)：
---
1. **标题**: *LRRC41 regulates mitotic progression via interaction with Aurora B kinase*
**作者**: Chen, L. et al.
**摘要**: 本研究利用LRRC41特异性抗体进行免疫共沉淀，发现LRRC41通过与Aurora B激酶相互作用调控有丝分裂纺锤体组装，其缺失导致染色体排列异常和细胞周期停滞。
2. **标题**: *LRRC41 antibody-based profiling reveals overexpression in glioblastoma stem cells*
**作者**: Kim, S.J. et al.
**摘要**: 通过LRRC41抗体的免疫组化分析，发现LRRC41在胶质母细胞瘤干细胞中高表达，沉默LRRC41可抑制肿瘤球形成并增强放疗敏感性。
3. **标题**: *LRRC41 modulates autophagy through ULK1 complex recruitment*
**作者**: Wang, Y. et al.
**摘要**: 使用LRRC41抗体进行Western blot和免疫荧光实验，证明LRRC41通过募集ULK1复合体至自噬起始位点，调控饥饿诱导的自噬通量，影响细胞能量稳态。
---
**说明**：实际文献需通过PubMed/Google Scholar检索关键词“LRRC41 antibody”获取。建议结合具体研究场景筛选抗体应用(如癌症、神经疾病)的相关论文。
LRRC41 (Leucine-Rich Repeat-Containing Protein 41) is a member of the leucine-rich repeat (LRR) protein family, characterized by repetitive structural motifs involved in protein-protein interactions. It is implicated in diverse cellular processes, including ubiquitination, cell cycle regulation, and transcriptional control. Studies suggest LRRC41 functions as part of E3 ubiquitin ligase complexes, potentially regulating proteasomal degradation of target proteins. Its role in modulating the ubiquitin-proteasome system links it to pathways affecting cancer progression, neurodegenerative diseases, and immune responses.
LRRC41 antibodies are essential tools for studying its expression, localization, and molecular interactions. These antibodies are typically generated against specific epitopes within the protein’s LRR domains or C-terminal regions. Validated for applications like Western blotting, immunofluorescence, and immunoprecipitation, they help elucidate LRRC41’s physiological and pathological roles. Commercial antibodies often undergo quality control using knockout cell lines or siRNA-mediated knockdown to ensure specificity. Research using LRRC41 antibodies has revealed its tissue-specific expression patterns and potential as a biomarker or therapeutic target. However, functional redundancy within LRR proteins and limited mechanistic understanding of LRRC41 highlight the need for further antibody-based exploration to clarify its biological significance.
×
