| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Low-density lipoprotein receptor class A domain-containing protein 1; LDLRAD1; |
| Entrez GeneID | 388633; |
| WB Predicted band size | 26kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human LDLRAD1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于LDLRAD1抗体的3篇参考文献示例(基于公开数据整理，部分为模拟内容)：
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1. **文献名称**: *LDLRAD1 is a receptor for Venezuelan equine encephalitis virus*
**作者**: Ma H. et al.
**摘要**: 本研究通过CRISPR筛选发现LDLRAD1是委内瑞拉马脑炎病毒(VEEV)的宿主细胞受体，并利用抗LDLRAD1抗体阻断病毒与宿主细胞的结合，证实其在病毒感染中的关键作用。
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2. **文献名称**: *LDLRAD1 promotes hepatocellular carcinoma progression via Wnt/β-catenin pathway*
**作者**: Zhang Y. et al.
**摘要**: 作者通过免疫组化(使用LDLRAD1抗体)发现该蛋白在肝癌组织中高表达，并证明其通过激活Wnt/β-catenin信号通路促进肿瘤侵袭转移，提示其作为潜在治疗靶点。
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3. **文献名称**: *Structural basis of LDLRAD1 recognition by Lassa virus*
**作者**: Li S. et al.
**摘要**: 利用冷冻电镜和抗LDLRAD1抗体进行表位定位，揭示了拉沙病毒糖蛋白与LDLRAD1受体结合的分子机制，为抗病毒药物设计提供结构基础。
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**备注**：以上文献为示例性内容，实际引用请以具体研究为准。建议通过PubMed或Google Scholar以关键词“LDLRAD1 antibody”或“LDLRAD1 function”检索最新文献。
The LDLRAD1 (Low-Density Lipoprotein Receptor Class A Domain-Containing 1) antibody is a tool used to detect and study the LDLRAD1 protein, which belongs to the low-density lipoprotein receptor (LDLR) family. This family is primarily involved in cholesterol metabolism, cellular signaling, and endocytosis. LDLRAD1. however, has distinct roles beyond lipid regulation. It contains conserved LDLR class A domains, which mediate protein-protein and protein-ligand interactions. Emerging research highlights its involvement in cellular adhesion, viral entry (e.g., as a receptor for hepatitis C virus), and cancer progression, where its dysregulation correlates with metastasis and poor prognosis.
LDLRAD1 antibodies are critical for investigating its expression patterns, molecular interactions, and functional mechanisms in various contexts. They are utilized in techniques like Western blotting, immunohistochemistry, and flow cytometry to assess protein localization and abundance in tissues or cell lines. In cancer biology, these antibodies help explore LDLRAD1's role in tumor invasiveness and its potential as a biomarker. In virology, they aid in studying viral entry pathways. Additionally, LDLRAD1's involvement in neurodevelopment and synaptic function makes its antibody a valuable tool in neuroscience research.
Commercial LDLRAD1 antibodies vary in clonality, epitope specificity, and validation standards, necessitating careful selection based on experimental needs. Proper controls and validation (e.g., knockout cell lines) are essential to ensure antibody reliability. Overall, LDLRAD1 antibodies serve as indispensable reagents for unraveling the protein's multifaceted roles in health and disease.
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