| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | low density lipoprotein receptor-related protein 11; MANSC3; |
| Entrez GeneID | 84918; |
| WB Predicted band size | 50kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human LRP11. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于LRP11抗体的示例参考文献(均为虚构，仅供格式参考)：
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1. **文献名称**: *LRP11 regulates cancer cell invasion via Wnt/β-catenin signaling*
**作者**: Zhang Y, et al.
**摘要**: 本研究利用抗LRP11抗体进行免疫沉淀和Western blot分析，发现LRP11通过与β-catenin相互作用激活Wnt信号通路，促进结直肠癌细胞的侵袭和转移。
2. **文献名称**: *Development of a monoclonal antibody targeting LRP11 for diagnostic applications*
**作者**: Smith J, et al.
**摘要**: 报道了一种新型抗LRP11单克隆抗体的开发与验证，该抗体在免疫组化中特异性识别肿瘤组织中的LRP11蛋白，显示其在癌症病理诊断中的潜在应用。
3. **文献名称**: *LRP11 knockdown suppresses lipid metabolism in hepatocytes*
**作者**: Tanaka K, et al.
**摘要**: 通过抗LRP11抗体介导的siRNA递送系统，研究发现LRP11缺失会抑制肝细胞脂质代谢相关基因表达，提示其在代谢性疾病中的作用机制。
4. **文献名称**: *LRP11 interacts with viral proteins to modulate host immune response*
**作者**: Chen L, et al.
**摘要**: 利用抗LRP11抗体进行共聚焦显微镜和Co-IP实验，揭示了LRP11与流感病毒蛋白的相互作用，可能通过调节宿主免疫通路影响病毒感染进程。
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**注意**：以上文献为示例，实际文献需通过PubMed、Google Scholar等数据库检索关键词(如“LRP11 antibody”、“LRP11 function”)。如需真实文献，建议查询相关学术平台。
**Background of LRP11 Antibody**
The Low-Density Lipoprotein Receptor-Related Protein 11 (LRP11), also known as LRP-11 or LRPR, is a transmembrane glycoprotein belonging to the LDL receptor family. This family is characterized by roles in endocytic pathways, cell signaling, and lipid metabolism. LRP11 contains structural motifs typical of its family, including epidermal growth factor (EGF)-like repeats and a cytoplasmic domain, but its precise physiological functions remain less defined compared to well-studied members like LRP1 or LDLR.
Emerging studies suggest LRP11 may play roles in intracellular trafficking, Wnt signaling modulation, and cellular communication. It has been implicated in pathological processes, such as cancer progression and neurodegenerative disorders, though mechanistic insights are limited. For example, LRP11 overexpression has been observed in certain cancers, potentially influencing tumor invasiveness or drug resistance.
Antibodies targeting LRP11 are critical tools for investigating its expression, localization, and function. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect LRP11 in cell lines or tissue samples. Commercial LRP11 antibodies are typically raised against specific epitopes, such as cytoplasmic or extracellular domains, and validated for specificity across species (e.g., human, mouse).
Current research focuses on clarifying LRP11’s interactions with signaling partners and its therapeutic potential. However, the limited availability of high-quality, well-characterized antibodies remains a challenge, underscoring the need for rigorous validation in diverse experimental models.
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