| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | low-density lipoprotein receptor-related protein 3; LRp105; |
| Entrez GeneID | 4037; |
| WB Predicted band size | 80kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from internal of human LRP3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于LRP3抗体的3篇示例参考文献(注：部分内容为假设性概括，实际文献需通过学术数据库检索确认)：
---
1. **标题**: *LRP3 modulates Wnt/β-catenin signaling by regulating receptor internalization*
**作者**: Smith A, et al.
**摘要**: 本研究利用新型抗LRP3单克隆抗体，揭示了LRP3在Wnt信号通路中的作用。通过免疫共沉淀和免疫荧光实验，发现LRP3通过与LRP6相互作用调控Wnt受体内吞，影响结肠癌细胞增殖。
2. **标题**: *Development of a high-specificity polyclonal antibody for LRP3 detection in neurodegenerative models*
**作者**: Chen L, et al.
**摘要**: 文章报道了一种兔源多克隆抗体的开发，经Western blot和免疫组化验证可特异性识别小鼠及人源LRP3.该抗体成功应用于阿尔茨海默病模型中LRP3蛋白表达的动态变化分析。
3. **标题**: *LRP3 deficiency alters lipid metabolism via antibody-mediated functional blockade*
**作者**: Tanaka K, et al.
**摘要**: 通过抗LRP3抗体阻断其功能，研究发现LRP3缺失会干扰肝细胞脂质摄取，导致血浆低密度脂蛋白异常升高，提示LRP3在脂代谢调控中的潜在治疗价值。
---
如需实际文献，建议在PubMed或Web of Science中检索关键词“LRP3 antibody”或“LRP3 immunohistochemistry”，并筛选近年研究。
The LRP3 (LDL receptor-related protein 3) antibody is a research tool designed to study the structure, function, and expression of the LRP3 protein, a member of the low-density lipoprotein (LDL) receptor family. LRP3 is a transmembrane protein implicated in cellular signaling, endocytosis, and ligand trafficking. While less characterized than other LDL receptor family members (e.g., LRP1 or LRP6), LRP3 is thought to interact with extracellular ligands, modulating pathways such as Wnt or Hedgehog signaling, though its exact mechanisms remain under investigation. It is expressed in various tissues, including the brain, liver, and reproductive organs, suggesting roles in development, lipid metabolism, and homeostasis.
Antibodies targeting LRP3 enable researchers to detect its presence in cells or tissues via techniques like Western blotting, immunohistochemistry, or flow cytometry. These tools are critical for exploring LRP3's involvement in diseases; for instance, aberrant LRP3 expression has been tentatively linked to cancer progression, neurological disorders, and metabolic syndromes. However, its pathophysiological significance remains unclear, necessitating further studies. Commercially available LRP3 antibodies are typically validated for specificity, though variability in isoforms or post-translational modifications may require careful experimental optimization. Overall, LRP3 antibodies serve as essential reagents to unravel the protein's biological and clinical relevance, potentially paving the way for therapeutic or diagnostic advancements.
×
