| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Endopeptidase S1P; KIAA0091; MBTP1; MBTPS1; membrane-bound transcription factor peptidase |
| Entrez GeneID | 8720; |
| WB Predicted band size | 19kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from C-terminal of human MBTPS1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于MBTPS1抗体的虚构参考文献示例(基于领域知识模拟，实际文献需通过学术数据库检索)：
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1. **文献名称**: *"MBTPS1 Antibody Validation in Cholesterol Homeostasis Studies"*
**作者**: Smith J, et al. (2021)
**摘要**: 本研究验证了MBTPS1特异性抗体在检测细胞中S1P蛋白酶活性中的应用，证明其在低氧条件下通过调控SREBP通路影响胆固醇合成，抗体在Western blot和免疫荧光中表现出高特异性。
2. **文献名称**: *"Role of MBTPS1 in Viral Entry: Insights from Antibody-Based Inhibition"*
**作者**: Lee H, Yamamoto A (2020)
**摘要**: 通过使用MBTPS1中和抗体，研究发现该蛋白在包膜病毒(如埃博拉病毒)的宿主细胞膜融合过程中起关键作用，抗体阻断可显著降低病毒感染效率。
3. **文献名称**: *"MBTPS1 Expression in Neurodegenerative Disease Models"*
**作者**: García-Ruiz C, et al. (2022)
**摘要**: 利用MBTPS1多克隆抗体对阿尔茨海默病模型小鼠脑组织进行免疫组化分析，发现其在内质网应激反应中异常激活，与tau蛋白病理相关。
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建议通过PubMed或Web of Science检索实际文献(关键词：MBTPS1 antibody, S1P protease, site-1 protease)。真实研究多聚焦于其分子机制、疾病关联及抗体工具的开发应用。
MBTPS1 (Membrane-Bound Transcription Factor Peptidase, Site 1), also known as S1P (Site-1 Protease), is a serine protease encoded by the MBTPS1 gene. It plays a critical role in regulated intramembrane proteolysis (RIP), a process essential for activating transmembrane transcription factors. MBTPS1 is localized in the endoplasmic reticulum and Golgi apparatus, where it cleaves substrate proteins such as sterol regulatory element-binding proteins (SREBPs) and activating transcription factor 6 (ATF6). These substrates are involved in lipid metabolism, endoplasmic reticulum stress response, and cellular homeostasis. Dysregulation of MBTPS1 has been linked to metabolic disorders, neurodegenerative diseases, and cancers, making it a target for therapeutic research.
MBTPS1 antibodies are immunological tools designed to detect and study the expression, localization, and function of the MBTPS1 protein. They are commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate MBTPS1's role in cellular processes. Polyclonal and monoclonal antibodies targeting specific epitopes (e.g., catalytic domains or regulatory regions) enable researchers to explore MBTPS1's interaction with substrates or its activity under varying physiological or pathological conditions. Validation of these antibodies includes specificity tests using knockout cell lines or tissues to avoid cross-reactivity with related proteases (e.g., MBTPS2/S2P). Studies utilizing MBTPS1 antibodies have contributed to understanding its involvement in lipid biosynthesis, stress signaling, and disease mechanisms, highlighting its potential as a biomarker or therapeutic target.
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