| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Microtubule-associated protein 9; Aster-associated protein; ASAP; |
| Entrez GeneID | 79884; |
| WB Predicted band size | 74kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human MAP9. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MAP9抗体的模拟参考文献示例(实际文献需通过学术数据库检索确认)：
1. **文献名称**: *MAP9 expression correlates with poor prognosis in glioblastoma*
**作者**: Smith A, et al.
**摘要**: 研究通过免疫组化(使用MAP9特异性抗体)发现，MAP9在胶质瘤组织中高表达，且与患者生存期缩短和肿瘤侵袭性增强相关，提示其作为预后标志物的潜力。
2. **文献名称**: *Role of MAP9 in microtubule stabilization during mitosis*
**作者**: Chen L, Wang Y.
**摘要**: 利用MAP9抗体进行免疫荧光和Western blot，揭示了MAP9在调控有丝分裂期微管动力学中的作用，并证明其缺失导致染色体排列异常和细胞周期停滞。
3. **文献名称**: *MAP9 antibody-based screening identifies its interaction with Aurora kinases*
**作者**: Gupta R, et al.
**摘要**: 通过免疫共沉淀(抗MAP9抗体)结合质谱分析，发现MAP9与Aurora激酶家族存在相互作用，提示其在有丝分裂信号通路中的协同调控机制。
4. **文献名称**: *MAP9 modulates chemoresistance in ovarian cancer cells*
**作者**: Tanaka H, et al.
**摘要**: 研究使用MAP9抗体检测紫杉醇处理后的卵巢癌细胞，发现MAP9表达上调与耐药性相关，敲低MAP9可增强化疗敏感性，为靶向治疗提供新思路。
**注意**：以上内容为模拟生成，实际文献需通过PubMed、Google Scholar等平台检索关键词“MAP9 antibody”或“Microtubule-associated protein 9”获取。
MAP9 (Microtubule-Associated Protein 9) is a conserved protein involved in regulating microtubule dynamics and mitotic spindle organization during cell division. It plays a critical role in maintaining genomic stability by ensuring proper chromosome segregation and spindle assembly. MAP9 interacts with components of the γ-tubulin ring complex and promotes microtubule nucleation, essential for bipolar spindle formation. Dysregulation of MAP9 has been linked to mitotic errors, aneuploidy, and cancer progression, with studies suggesting its overexpression in certain tumors.
Antibodies targeting MAP9 are vital tools for studying its expression, localization, and function in cellular processes. They enable detection via techniques like immunofluorescence, Western blotting, and immunohistochemistry, aiding research into cell cycle regulation and cancer mechanisms. MAP9 antibodies often recognize specific epitopes within its N-terminal or C-terminal domains, with validation in knockdown or knockout models to confirm specificity. These reagents have advanced understanding of MAP9's role in development, tissue homeostasis, and disease, highlighting its potential as a therapeutic target or diagnostic marker in oncology.
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