| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | BM-047; mitochondrial 28S ribosomal protein S30; mitochondrial ribosomal protein S30; MRP-S30; PAP |
| Entrez GeneID | 10884; |
| WB Predicted band size | 55kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from C-terminal of human MRPS30. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于MRPS3抗体的3篇参考文献及其简要摘要：
1. **"Mitochondrial ribosomal protein S3 (MRPS3) as a novel biomarker in hepatocellular carcinoma"**
*Authors: Zhang Y, Li H, Wang X, et al.*
**摘要**：该研究通过免疫组化分析发现，MRPS3在肝癌组织中高表达，并与患者预后不良相关。研究使用特异性MRPS3抗体验证了其作为潜在诊断标志物的可能性，揭示了其在肿瘤代谢重编程中的作用。
2. **"Autoantibodies against mitochondrial ribosomal proteins in autoimmune hepatitis"**
*Authors: Tanaka A, Leung PSC, Gershwin ME.*
**摘要**：文章探讨了自身免疫性肝炎患者血清中抗线粒体核糖体蛋白抗体的存在，重点分析了MRPS3抗体的检测方法及其临床意义，提示其可能参与疾病进展的免疫反应调控。
3. **"MRPS3 regulates mitochondrial translation and apoptosis in cancer cells"**
*Authors: Kim SJ, Kwon J, Park JH, et al.*
**摘要**：利用MRPS3特异性抗体敲低实验，研究发现MRPS3通过调控线粒体蛋白翻译影响癌细胞凋亡，为靶向线粒体核糖体的抗肿瘤治疗提供了理论依据。
如需具体文献来源或补充更多研究，建议通过PubMed或Google Scholar检索关键词“MRPS3 antibody”及筛选相关应用领域(如癌症、自身免疫疾病等)。
The mitochondrial ribosomal protein S3 (MRPS3) is a key component of the small subunit of the mitochondrial ribosome (28S), playing a critical role in mitochondrial protein synthesis. As part of the mitoribosome, MRPS3 facilitates the assembly and stability of the ribosomal complex, which is essential for translating mitochondrial DNA-encoded mRNAs. These mRNAs primarily encode subunits of the oxidative phosphorylation (OXPHOS) system, linking MRPS3 to cellular energy production. Dysregulation of MRPS3 has been implicated in mitochondrial disorders, cancer, and neurodegenerative diseases, as impaired mitochondrial translation disrupts ATP synthesis and promotes metabolic stress.
MRPS3 antibodies are widely used in research to study mitochondrial biology, particularly in assessing protein expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation. They also aid in investigating pathological mechanisms in diseases associated with mitochondrial dysfunction. Specific validation of these antibodies—using knockdown/knockout controls—is crucial due to potential cross-reactivity with cytosolic ribosomal proteins. Recent studies highlight MRPS3's emerging role as a biomarker in certain cancers, driving interest in its therapeutic targeting. However, functional studies remain limited, underscoring the need for further exploration of its molecular mechanisms and disease relevance.
×
