关键信息
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基因名
LAPTM4B
- 应用
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别名
LAPTM4B; PSEC0001; Lysosomal-associated transmembrane protein 4B; Lysosome-associated transmembrane protein 4-beta
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q86VI4
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表达区间
1-226aa
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氨基酸序列
MKMVAPWTRFYSNSCCLCCHVRTGTILLGVWYLIINAVVLLILLSALADPDQYNFSSSELGGVFEFMDDANMCIAIAISLLMILICAMATYGAYKQRAAWIIPFFCYQIFDFALNMLVAITVLIYPNSIQEYTRQLPPNFPYRDDVMSVNPTCLVLIILLFISIILTFKGYLISCVWNCYRYINGRNSSDVLVYVTSNDTTVLLPPYDDATVNGAAKEPPPPYVSA
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分子量
50.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
LAPTM4B (lysosomal-associated protein transmembrane 4 beta) is a transmembrane protein implicated in various cellular processes, including lysosomal function, signal transduction, and the regulation of cellular trafficking. It has drawn significant attention in cancer research due to its overexpression in multiple tumor types, suggesting a potential role in tumor progression and resistance to chemotherapy. Studies indicate that LAPTM4B may facilitate the survival of cancer cells by modulating lysosomal function and promoting autophagy, processes critical for maintaining cellular homeostasis under stress conditions. Furthermore, the protein's involvement in the regulation of immune responses underscores its biological significance beyond oncology. Given these functions, researchers are investigating LAPTM4B as a potential biomarker for cancer prognosis and a target for therapeutic intervention. The exploration of LAPTM4B recombinant proteins aims to elucidate its molecular mechanisms and interactions, providing insights that could lead to the development of novel cancer treatments and diagnostic tools. Understanding the structure and functional dynamics of LAPTM4B is crucial in deciphering its role in health and disease, particularly in the context of cancer biology, where it may influence tumor microenvironments and response to therapy. As such, the characterization of LAPTM4B recombinant proteins represents an important step towards harnessing their potential for therapeutic applications in oncology.
