Rabbit Polyclonal MRPL5 Antibody

The MRPL5 antibody is a research tool designed to detect mitochondrial ribosomal protein L5 (MRPL5), a component of the mitochondrial ribosome large subunit (39S). MRPL5 is encoded by nuclear DNA and imported into mitochondria, where it contributes to the assembly and function of mitochondrial ribosomes. These ribosomes are essential for translating mitochondrial DNA-encoded mRNAs, particularly subunits of the oxidative phosphorylation (OXPHOS) complexes critical for ATP production. Antibodies targeting MRPL5 are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study mitochondrial protein synthesis, ribosome biogenesis, and mitochondrial dysfunction. Research involving MRPL5 antibodies often focuses on mitochondrial diseases, cancer, and neurodegenerative disorders linked to impaired OXPHOS activity. Mutations or dysregulation of MRPL5 have been associated with conditions like combined oxidative phosphorylation deficiency and certain cancers, reflecting its role in maintaining mitochondrial health. Validated MRPL5 antibodies help elucidate cellular responses to metabolic stress, gene expression changes in disease models, and mechanisms of mitochondrial translation regulation. Specificity and cross-reactivity validation across species (e.g., human, mouse) are critical for reliable experimental outcomes.