| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Monocarboxylate transporter 8; MCT 8; MCT 7; Solute carrier family 16 member 2; X-linked PEST-containing transporter |
| Entrez GeneID | 6567; |
| WB Predicted band size | 60kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human SLC16A2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SLC16A2(MCT8)抗体的模拟参考文献示例(非真实文献，供格式参考)：
1. **标题**：Monocarboxylate Transporter 8 (MCT8) Antibody Validation in Thyroid Hormone Transport Studies
**作者**：Smith J, et al.
**摘要**：研究开发了一种特异性识别SLC16A2/MCT8蛋白的抗体，通过免疫印迹和免疫组化验证其在甲状腺激素转运缺陷模型中的表达变化，揭示了MCT8在中枢神经系统发育中的关键作用。
2. **标题**：Characterization of SLC16A2 Antibody for Detecting Mutations in Allan-Herndon-Dudley Syndrome
**作者**：Chen L, et al.
**摘要**：通过患者细胞系和小鼠模型，验证了一种高灵敏度的SLC16A2抗体，用于检测MCT8蛋白功能缺失突变，为罕见病诊断提供工具支持。
3. **标题**：Localization of MCT8 in Human Placenta Using a Novel Polyclonal Antibody
**作者**：Garcia R, et al.
**摘要**：报道了一种新型多克隆抗体，通过免疫荧光技术揭示MCT8在胎盘组织中的表达模式，提示其在母胎甲状腺激素转运中的潜在调控机制。
4. **标题**：SLC16A2 Antibody-Based Screening for Drug-Induced MCT8 Inhibition
**作者**：Wang T, et al.
**摘要**：利用SLC16A2特异性抗体建立高通量筛选平台，评估药物对MCT8介导的甲状腺激素摄取的影响，为药物安全性研究提供方法学基础。
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**注意**：以上为模拟内容，实际文献需通过PubMed、Google Scholar等平台检索关键词(如"SLC16A2 antibody"、"MCT8 antibody validation")获取。
The SLC16A2 antibody targets the solute carrier family 16 member 2 (SLC16A2), also known as monocarboxylate transporter 8 (MCT8), a protein encoded by the SLC16A2 gene. MCT8 is a critical thyroid hormone transporter, facilitating the cellular uptake of triiodothyronine (T3) and thyroxine (T4) across plasma membranes. It is highly expressed in tissues such as the brain, liver, kidneys, and thyroid, playing a vital role in neurodevelopment and metabolic regulation. Mutations in SLC16A2 are linked to Allan-Herndon-Dudley syndrome (AHDS), a rare X-linked disorder characterized by severe intellectual disability, hypotonia, and abnormal thyroid hormone levels.
SLC16A2 antibodies are essential tools for studying MCT8 expression, localization, and function in both normal and pathological conditions. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate tissue-specific distribution, protein interactions, and dysregulation mechanisms in disease models. Research utilizing these antibodies has advanced understanding of thyroid hormone transport deficiencies, neuronal development impairments, and potential therapeutic strategies for AHDS. Additionally, studies explore MCT8's role in cancer, as altered expression may influence tumor metabolism and progression.
Structurally, MCT8 contains 12 transmembrane domains, and antibodies targeting specific epitopes help map functional regions or detect pathogenic variants. Commercial SLC16A2 antibodies are typically validated for specificity and sensitivity, ensuring reliability in experimental and diagnostic applications.
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