| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | egfl5; megf9; multiple egf-like-domains 9; |
| Entrez GeneID | 1955; |
| WB Predicted band size | 63kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human MEGF9. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MEGF9抗体的3篇参考文献示例(注：以下内容为模拟示例，实际文献可能需要通过学术数据库核实)：
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1. **标题**: *"A novel monoclonal antibody targeting MEGF9 reveals its role in neuronal migration"*
**作者**: Tanaka, K. et al.
**摘要**: 研究开发了一种特异性抗MEGF9单克隆抗体，通过免疫组织化学和Western blot验证其在哺乳动物神经元中的表达。结果表明MEGF9在小脑颗粒细胞迁移中起关键作用，抗体可用于研究发育性神经疾病模型。
2. **标题**: *"MEGF9 antibody-based profiling identifies stromal expression patterns in colorectal cancer"*
**作者**: Chen, L. et al.
**摘要**: 利用兔源多克隆抗体分析MEGF9在结直肠癌组织中的表达，发现其在肿瘤相关成纤维细胞中高表达，并与患者生存率负相关，提示其作为潜在生物标志物的价值。
3. **标题**: *"Characterization of MEGF9 in phagocytosis: Insights from a custom polyclonal antibody"*
**作者**: Rodriguez, S. et al.
**摘要**: 研究通过制备并验证抗MEGF9多克隆抗体，发现该蛋白在巨噬细胞吞噬过程中富集于吞噬体膜，表明其可能参与调控胞葬作用(efferocytosis)的分子机制。
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**备注**：若需真实文献，建议通过PubMed或Google Scholar以关键词“MEGF9 antibody”或“anti-MEGF9”检索，并筛选涉及抗体开发或功能研究的论文。部分研究可能未在摘要中明确提及抗体，需查阅全文方法学部分。
The MEGF9 (Multiple Epidermal Growth Factor-like Domains 9) antibody is a tool used to detect and study the MEGF9 protein, a member of the low-density lipoprotein (LDL) receptor family. MEGF9 is a transmembrane protein characterized by multiple epidermal growth factor (EGF)-like repeats and a conserved cytoplasmic domain. It is expressed in various tissues, including the brain, kidneys, and developing organs, where it plays roles in cell adhesion, signaling, and tissue morphogenesis. Studies suggest its involvement in neuronal development, synaptic organization, and possibly immune regulation, though its precise biological functions remain under investigation.
MEGF9 antibodies are primarily employed in research to map protein expression patterns, assess interactions with ligands or other receptors, and explore its role in diseases. For instance, MEGF9 mutations have been linked to developmental disorders, such as Temple-Baraitser syndrome, characterized by neurodevelopmental defects and epilepsy. Antibodies targeting specific epitopes (e.g., extracellular EGF-like domains or intracellular regions) enable techniques like immunohistochemistry, Western blotting, and immunofluorescence to visualize protein localization and quantify expression levels.
Commercial MEGF9 antibodies are typically monoclonal or polyclonal, validated for specificity in human, mouse, or rat models. Researchers utilize these tools to uncover MEGF9's contributions to cellular processes and pathologies, with potential implications for understanding neurodevelopmental disorders or designing therapeutic strategies.
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