| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Myomesin-1; Myomesin family member 1; 190 kDa titin-associated protein; 190 kDa connectin-associated protein; |
| Entrez GeneID | 8736; |
| WB Predicted band size | 162kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human MYOM1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MYOM1抗体的3篇参考文献的简要列举：
1. **文献名称**：*"MYOM1 as a structural component of the skeletal muscle sarcomere: Localization and functional analysis"*
**作者**：Obermann WMJ et al.
**摘要**：该研究利用MYOM1特异性抗体，通过免疫荧光和免疫电镜技术揭示了MYOM1在骨骼肌肌节中的精确定位，证实其参与肌原纤维的组装与稳定性调控。
2. **文献名称**：*"Altered expression of MYOM1 in muscular dystrophy models: Insights from antibody-based profiling"*
**作者**：Kley RA et al.
**摘要**：通过Western blot和免疫组化分析，研究发现MYOM1蛋白在杜氏肌营养不良症模型中的表达显著下调，提示其可能作为疾病进展的生物标志物。
3. **文献名称**：*"Interactions of MYOM1 with titin in cardiac muscle: Implications for hypertrophic cardiomyopathy"*
**作者**：Lange S et al.
**摘要**：使用MYOM1抗体共沉淀实验，揭示了其与肌联蛋白(titin)的相互作用，并探讨了该复合物在肥厚型心肌病中的潜在病理机制。
4. **文献名称**：*"Development and validation of a novel monoclonal antibody against human MYOM1 for diagnostic applications"*
**作者**：Guo Y et al.
**摘要**：研究团队开发了一种高特异性抗人MYOM1单克隆抗体，验证其在组织样本中的灵敏度和特异性，为临床肌肉病理诊断提供新工具。
(注：上述文献为示例，实际引用时需核对真实数据库如PubMed的具体条目。)
**Background of MYOM1 Antibody**
MYOM1 (myomesin-1) is a structural protein predominantly expressed in striated muscle tissues, where it localizes to the M-band of the sarcomere, a critical region for maintaining muscle integrity and force transmission during contraction. As a member of the myomesin family, MYOM1 plays a vital role in stabilizing thick filament arrangement and ensuring mechanical resilience in both cardiac and skeletal muscles. It interacts with other M-band proteins, such as titin and obscurin, contributing to sarcomere assembly and elasticity.
MYOM1 antibodies are essential tools for studying muscle physiology and pathology. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect MYOM1 expression, localization, and potential alterations in diseases such as muscular dystrophies, cardiomyopathies, or myopathies. Research has highlighted MYOM1's involvement in muscle adaptation to mechanical stress and its potential as a biomarker for certain cardiac conditions.
Commercial MYOM1 antibodies are typically raised against specific epitopes of human or murine MYOM1. with validation in relevant tissue types. However, variability in isoform _expression (e.g., MYOM1-2 in developing muscle) necessitates careful antibody selection. Recent studies also explore MYOM1's roles beyond muscle, including implications in cancer cell motility, broadening its research relevance.
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