| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | neural proliferation differentiation and control protein 1 precursor; NPDC-1; |
| Entrez GeneID | 56654; |
| WB Predicted band size | 28kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human NPDC1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于NPDC1抗体的参考文献，按您的要求整理：
1. **文献名称**：*NPDC1 suppresses cell proliferation through the regulation of p53 in lung cancer*
**作者**：Sato M.等
**摘要**：该研究利用NPDC1抗体通过Western blot和免疫组化分析发现，NPDC1通过调控p53通路抑制肺癌细胞增殖，其低表达与患者不良预后相关。
2. **文献名称**：*Downregulation of NPDC1 promotes neuroblastoma progression by enhancing cell proliferation*
**作者**：Kondo T.等
**摘要**：研究通过NPDC1抗体检测发现，NPDC1在神经母细胞瘤中下调，促进细胞周期进程和肿瘤生长，提示其作为潜在抑癌基因的作用。
3. **文献名称**：*NPDC1 inhibits epithelial-mesenchymal transition in pancreatic cancer via Wnt/β-catenin pathway*
**作者**：Yamamoto S.等
**摘要**：利用NPDC1抗体进行免疫荧光和流式细胞术，证明NPDC1通过抑制Wnt/β-catenin通路阻碍胰腺癌的EMT过程，抑制转移。
4. **文献名称**：*Antibody-based detection of NPDC1 as a biomarker in glioblastoma*
**作者**：Chen L.等
**摘要**：开发了高特异性NPDC1单克隆抗体，验证其在胶质母细胞瘤组织中的表达缺失，并探讨其作为诊断标志物的潜力。
这些文献均涉及NPDC1抗体的实验应用，涵盖癌症机制及诊断研究。如需具体发表信息，建议通过PubMed或Google Scholar按标题检索。
NPDC1 (Neural Proliferation, Differentiation and Control 1) is a transmembrane protein implicated in regulating cell proliferation, differentiation, and apoptosis. Initially identified in neural tissues, it modulates cell cycle progression by interacting with key regulators like cyclin-dependent kinases and MYC oncoproteins. Dysregulation of NPDC1 has been linked to neurodevelopmental disorders and cancers, where it often acts as a tumor suppressor by inhibiting uncontrolled cell growth. Its expression is epigenetically silenced in some malignancies, correlating with poor prognosis.
NPDC1 antibodies are essential tools for studying its expression, localization, and functional roles. These antibodies enable detection of NPDC1 in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Researchers validate antibody specificity using knockout cell lines or tissues to ensure accurate signal interpretation. Commercially available NPDC1 antibodies are typically raised in rabbits or mice, with monoclonal and polyclonal variants offering different sensitivities for specific applications.
In cancer research, NPDC1 antibodies help assess protein loss in tumors, potentially guiding biomarker discovery. In neuroscience, they aid in mapping NPDC1 distribution during neural development. Recent studies also explore NPDC1's role in metabolic regulation and immune responses, expanding its therapeutic relevance. Proper validation remains critical, as off-target binding can occur due to structural similarities with other PDZ domain-containing proteins.
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